Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model

• Published in: Chemical communications (Cambridge, England) Vol. 58; no. 22; pp. 3629 - 3632
• Main Authors: Ni, Lu, Yamada, Takeshi, Murata, Asako, Nakatani, Kazuhiko
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 15.03.2022
• Subjects: Binding sites; Dimers; Ligands; RNA - genetics; RNA - metabolism; RNA Precursors - genetics; RNA Splicing; RNA, Circular; Splicing

Circular RNA (circRNA) is a covalently closed single-stranded RNA produced from pre-mRNAs via back-splicing reaction, an alternative form of splicing. Here, we show naphthyridine carbamate dimer (NCD) upregulating the production of a circRNA from a pre-mRNA containing NCD-binding site UGGAA/UGGAA in...