Demonstration of a convergent approach to UV-polymerizable lipids bisDenPC and bisSorbPC

Lipids containing UV-polymerizable diene moieties, such as BisDenPC 1 and BisSorbPC 2, have been extremely useful for the construction of micelles and lipid bilayers. The published syntheses have yielded lipids with only a trimethylamine head group. We have improved the syntheses of these monomers b...

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Bibliographic Details
Published inTetrahedron letters Vol. 52; no. 29; pp. 3699 - 3701
Main Authors Jones, Ian W., Hall, H.K.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 20.07.2011
Elsevier
Subjects
Applied sciences
Chemistry
Chemistry, Organic
Colloidal state and disperse state
Construction
Derivatives
Dienes
Exact sciences and technology
General and physical chemistry
Heterocyclic compounds
Lipids
Micelles
Micelles. Thin films
Miscellaneous
Monomers
Organic chemistry
Physical Sciences
Physicochemistry of polymers
Polymerization
Polymers and radiations
Preparations and properties
Science & Technology
Tetrahedrons
Trimethylamine
ALCOHOLS
MEMBRANES
PHASE
ANALOGS
LIPOSOMES
BINDING
Phosphorus heterocycle
Dialkylamine
Trimethylamine
Cyclic compound
Photopolymerization
Micelle
Polymerization
Lipids
Dienic compound
Chemical synthesis
Bilayer
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Summary:Lipids containing UV-polymerizable diene moieties, such as BisDenPC 1 and BisSorbPC 2, have been extremely useful for the construction of micelles and lipid bilayers. The published syntheses have yielded lipids with only a trimethylamine head group. We have improved the syntheses of these monomers by a convergent method employing the Chabrier reaction of trimethylamine with a cyclic phospholane. This method can be extended to a variety of dialkylamine derivatives.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.11.090