GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis

GADD45 is a gene family consisting of GADD45A, GADD45B, and GADD45G that is often induced by DNA damage and other stress signals associated with growth arrest and apoptosis. Many of these roles are carried out via signaling mediated by p38 mitogen-activated protein kinases (MAPKs). The GADD45 protei...

Full description

Saved in:
Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 1360; p. 1
Main Authors Humayun, Arslon, Fornace, Jr, Albert J
Format Journal Article
LanguageEnglish
Published United States 01.01.2022
Subjects
Apoptosis - genetics
Cell Cycle Checkpoints
DNA Damage
Humans
Signal Transduction
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
GADD45
UV radiation
Oxidative stress
Cell cycle
Foxo3a
Tumorigenesis
BRCA1
MAPK
NFkappaB
Apoptosis
p53
Online AccessGet more information

Cover

More Information
Summary:GADD45 is a gene family consisting of GADD45A, GADD45B, and GADD45G that is often induced by DNA damage and other stress signals associated with growth arrest and apoptosis. Many of these roles are carried out via signaling mediated by p38 mitogen-activated protein kinases (MAPKs). The GADD45 proteins can contribute to p38 activation either by activation of upstream kinase(s) or by direct interaction, as well as suppression of p38 activity in certain cases. In vivo, there are important tissue and cell type specific differences in the roles for GADD45 in MAPK signaling. In addition to being p53-regulated, GADD45A has also been found to contribute to p53 activation via p38. Like other stress and signaling proteins, GADD45 proteins show complex regulation and numerous effectors. More recently, aberrant GADD45 expression has been found in several human cancers, but the mechanisms behind these findings largely remain to be understood.
ISSN:0065-2598
DOI:10.1007/978-3-030-94804-7_1