N6-Methyladenosine and Viral Infection
N 6 -methyladenosine (m 6 A), as a dynamic posttranscriptional RNA modification, recently gave rise to the field of viral epitranscriptomics. The interaction between virus and host is affected by m 6 A. Multiple m 6 A-modified viral RNAs have been observed. The epitranscriptome of m 6 A in host cell...
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Published in | Frontiers in microbiology Vol. 10; p. 417 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
05.03.2019
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Subjects | |
Online Access | Get full text |
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Summary: | N
6
-methyladenosine (m
6
A), as a dynamic posttranscriptional RNA modification, recently gave rise to the field of viral epitranscriptomics. The interaction between virus and host is affected by m
6
A. Multiple m
6
A-modified viral RNAs have been observed. The epitranscriptome of m
6
A in host cells are altered after viral infection. The expression of viral genes, the replication of virus and the generation of progeny virions are influenced by m
6
A modifications in viral RNAs during virus infection. Meanwhile, the decorations of m
6
A in host mRNAs can make viral infections more likely to happen or can enhance the resistance of host to virus infection. However, the mechanism of m
6
A regulation in viral infection and host immune response has not been thoroughly elucidated to date. With the development of sequencing-based biotechnologies, transcriptome-wide mapping of m
6
A in viruses has been achieved, laying the foundation for expanding its functions and corresponding mechanisms. In this report, we summarize the positive and negative effects of m
6
A in distinct viral infection. Given the increasingly important roles of m
6
A in diverse viruses, m
6
A represents a novel potential target for antiviral therapy. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reviewed by: Hao Lin, University of Electronic Science and Technology of China, China; Takashi Irie, Hiroshima University, Japan This article was submitted to Virology, a section of the journal Frontiers in Microbiology Edited by: Herman W. Favoreel, Ghent University, Belgium |
ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2019.00417 |