A Japanese case of successful surgical resection of cerebral cavernous malformations with a CCM2 mutation

Cerebral cavernous malformations (CCMs) are congenital abnormalities of cerebral vessels. Surgical resection is rarely considered for the control of epilepsy in a first seizure patient with vascular malformation. In contrast, lesions that produce repetitive or progressive symptoms should be consider...

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Bibliographic Details
Published inNeurology and clinical neuroscience Vol. 10; no. 5; pp. 255 - 258
Main Authors Nomura, Emi, Omote, Yoshio, Takemoto, Mami, Hishikawa, Nozomi, Nakano, Yumiko, Yunoki, Taijun, Morihara, Ryuta, Sasaki, Tatsuya, Akagawa, Hiroyuki, Abe, Koji, Yamashita, Toru
Format Journal Article
LanguageEnglish
Published Tokyo Wiley Subscription Services, Inc 01.09.2022
Subjects
CCM2
CCM2 protein
cerebral cavernous malformation
Congenital defects
drug‐resistant epilepsy
Epilepsy
Mutation
Patients
Seizures
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Summary:Cerebral cavernous malformations (CCMs) are congenital abnormalities of cerebral vessels. Surgical resection is rarely considered for the control of epilepsy in a first seizure patient with vascular malformation. In contrast, lesions that produce repetitive or progressive symptoms should be considered for surgical resection as treatment. Herein, we report a Japanese patient with a CCM2 mutation, c.609G>A (p.K203K) substitution, who showed drug‐resistant epilepsy and dramatic improvement after surgical resection.
ISSN:2049-4173
2049-4173
DOI:10.1111/ncn3.12649