Enprostil inhibits post‐prandial gastrin release: a dose—response study

SUMMARY In a double‐blind placebo‐controlled study in nine healthy volunteers, the effects of single doses of oral enprostil (8.75, 17.5, 35 and 70 μg), taken before a standard breakfast, were assessed on the post‐prandial release of gastrin into the plasma. All doses of enprostil caused a significa...

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Bibliographic Details
Published inAlimentary pharmacology & therapeutics Vol. 2; no. 4; pp. 317 - 323
Main Authors LANZON‐MILLER, S., ALLISON, M. C., POUNDER, R. E., BALL, S., HAMILTON, M. R., CHRONOS, N. A. F.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.08.1988
Subjects
Adult
Dose-Response Relationship, Drug
Double-Blind Method
Eating
Enprostil - pharmacology
Gastrins - metabolism
Humans
Male
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Summary:SUMMARY In a double‐blind placebo‐controlled study in nine healthy volunteers, the effects of single doses of oral enprostil (8.75, 17.5, 35 and 70 μg), taken before a standard breakfast, were assessed on the post‐prandial release of gastrin into the plasma. All doses of enprostil caused a significant dose‐related decrease in median post‐prandial plasma gastrin concentration (range from — 29 to — 44%). In the same subjects, two doses of 25 mg indomethacin caused a significant (38%) increase in median post‐prandial plasma gastrin concentration.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
content type line 23
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.1988.tb00703.x