Interactions between ricinus agglutinin and human IgM and IgG

Ricinus agglutinin, purified until homogeneous, precipitates serum glycoproteins with terminal nonreducing galactose residues including IgM and IgG. Almost 100% of IgM reacted with anti-IgM and ricinus agglutinin in quantitative precipitin tests. In similar tests, almost 100% of polyclonal IgG was p...

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Bibliographic Details
Published inScandinavian journal of immunology Vol. 4; no. 3; p. 287
Main Authors Saltvedt, E, Harboe, M, Følling, I, Olsnes, S
Format Journal Article
LanguageEnglish
Published England 01.01.1975
Subjects
Antibodies, Anti-Idiotypic
Humans
Immune Sera
Immunoglobulin G
Immunoglobulin M
Lactose
Lectins
Plant Lectins
Plants, Toxic
Precipitin Tests
Ricinus - immunology
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Summary:Ricinus agglutinin, purified until homogeneous, precipitates serum glycoproteins with terminal nonreducing galactose residues including IgM and IgG. Almost 100% of IgM reacted with anti-IgM and ricinus agglutinin in quantitative precipitin tests. In similar tests, almost 100% of polyclonal IgG was precipitated by excess anti-IgG, whereas only about 10% reacted with ricinus agglutinin. In quantitative precipitin analyses and affinity chromatography experiments with insolubilized ricinus agglutinin and isolated monoclonal IgG1 and IgG3 proteins, only IgG3 proteins reacted with ricinus agglutinin.
ISSN:0300-9475
DOI:10.1111/j.1365-3083.1975.tb02628.x