Reversal of pancuronium with edrophonium

Edrophonium was administered as a bolus of 2, 10 or 50 mg (0.03, 0.14 and 0.71 mg/kg) to antagonize neuromuscular block after pancuronium in man. Neuromuscular transmission was measured using "train-of-four" stimulation. Recovery started within 1 min, was maximum at 2 min and was then foll...

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Bibliographic Details
Published inAnaesthesia Vol. 34; no. 7; p. 614
Main Author Bevan, D R
Format Journal Article
LanguageEnglish
Published England 01.07.1979
Subjects
Adult
Aged
Dose-Response Relationship, Drug
Edrophonium - pharmacology
Humans
Kinetics
Middle Aged
Neuromuscular Junction - drug effects
Neuromuscular Junction - physiology
Pancuronium - antagonists & inhibitors
Synaptic Transmission - drug effects
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Summary:Edrophonium was administered as a bolus of 2, 10 or 50 mg (0.03, 0.14 and 0.71 mg/kg) to antagonize neuromuscular block after pancuronium in man. Neuromuscular transmission was measured using "train-of-four" stimulation. Recovery started within 1 min, was maximum at 2 min and was then followed by a plateau of slow continued improvement. The degree of recovery increased with larger doses of edrophonium and also was related to the total amount of pancuronium administered although reversal was attempted at the same degree of spontaneous recovery. There was no evidence of recurarisation or depolarising block.
ISSN:0003-2409
DOI:10.1111/j.1365-2044.1979.tb06359.x