A monoclonal antibody which differentiates between bound and free human secretory component

In this study a mouse monoclonal antibody ( LICR -LON- LC28 ) to human secretory component (SC) is reported. This antibody binds to free SC or to SC associated with IgA or IgM. It exhibits a 10-fold higher affinity for SC bound to IgA than for free SC. The affinity of the antibody for SC associated...

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Bibliographic Details
Published inEuropean journal of immunology Vol. 14; no. 4; p. 344
Main Authors Gore, M E, Bunnage, H J, McIlhinney, R A
Format Journal Article
LanguageEnglish
Published Germany 1984
Subjects
Antibodies, Monoclonal - immunology
Antibody Affinity
Antibody Specificity
Antigen-Antibody Reactions
Antigens
Histocytochemistry
Humans
Immunochemistry
Immunoglobulin A
Immunoglobulin Fragments
Membrane Proteins - immunology
Milk Proteins - immunology
Milk, Human - immunology
Mucin-1
Secretory Component
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Summary:In this study a mouse monoclonal antibody ( LICR -LON- LC28 ) to human secretory component (SC) is reported. This antibody binds to free SC or to SC associated with IgA or IgM. It exhibits a 10-fold higher affinity for SC bound to IgA than for free SC. The affinity of the antibody for SC associated with IgM is equivalent to that seen for free SC. LICR -LON- LC28 appears to be species specific and does not cross-react with other human milk proteins.
ISSN:0014-2980
DOI:10.1002/eji.1830140413