Squaramide‐Catalyzed Asymmetric Reactions

• Published in: Chemical record Vol. 17; no. 10; pp. 994 - 1018
• Main Authors: Zhao, Bo‐Liang, Li, Jun‐Hua, Du, Da‐Ming
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2017
• Subjects: asymmetric synthesis; Asymmetry; Bioactive compounds; Biological activity; Cascade chemical reactions; cascade reaction; Catalysts; Chemical bonds; Chemical reactions; Construction methods; hydrogen bond; Hydrogen bonding; Mannich reaction; Michael addition; organocatalysis squaramides; Michael addition; organocatalysis squaramides; asymmetric synthesis; cascade reaction; Mannich reaction; hydrogen bond
• ISSN: 1527-8999; 1528-0691
• DOI: 10.1002/tcr.201600140

Bifunctional squaramides have emerged as powerful hydrogen‐bonding catalysts for promoting a wide array of useful asymmetric reactions, which provides convenient methods for the construction of complex molecular structures and chiral biologically active compounds. This review highlights the recent advances of our research group in the chiral squaramide‐catalyzed asymmetric reactions, including Michael addition, Mannich reaction, aza‐Henry reaction, Strecker reaction as well as cascade or sequential reactions. Bifunctional squaramides have emerged as powerful hydrogen‐bonding catalysts for promoting a wide array of useful asymmetric reactions, which provides convenient methods for the construction of complex molecular structures and chiral biologically active compounds. This review highlights the recent advances of our research group in the chiral squaramide‐catalyzed asymmetric reactions, including Michael addition, Mannich reaction, aza‐Henry reaction, Strecker reaction as well as cascade or sequential reactions.