A longitudinal study of thyroid function in pregnancy

We undertook a prospective longitudinal study of thyroid function in 36 pregnant women. There were significant increases in thyroxin-binding globulin, thyrotropin, and triiodothyronine. Albumin, free thyroxin (measured by an analog and a nonanalog method), and the free thyroxin index were significan...

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Published inClinical chemistry (Baltimore, Md.) Vol. 35; no. 2; pp. 275 - 278
Main Authors PRICE, A, GRIFFITHS, H, MORRIS, B. W
Format Journal Article
LanguageEnglish
Published Washington, DC American Association for Clinical Chemistry 01.02.1989
Subjects
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Hormones. Regulation
Humans
Longitudinal Studies
Pregnancy - blood
Pregnancy - physiology
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prospective Studies
Serum Albumin - analysis
Thyroid Hormones - blood
Thyroid. Parathyroid. Ultimobranchial body
Vertebrates: endocrinology
Human
Aminoacid derivative hormone
Albumin
TSH
Thyroid gland
Glycoprotein hormone
Biological activity
Pregnancy
Proteins
Adenohypophyseal hormone
Thyroxine
TBPA
Thyroid hormone
Triiodothyronine
Woman
Quantitative analysis
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Summary:We undertook a prospective longitudinal study of thyroid function in 36 pregnant women. There were significant increases in thyroxin-binding globulin, thyrotropin, and triiodothyronine. Albumin, free thyroxin (measured by an analog and a nonanalog method), and the free thyroxin index were significantly decreased. Results for the free thyroxin methods were correlated with each other in each trimester. We could find no evidence for artifacts related to albumin or thyroxin-binding globulin with either method for free thyroxin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/35.2.275