Implications for glycosylated compounds and their anti-cancer effects

Glycosylated compounds are major secondary metabolites of plants, which have various therapeutic effects on human diseases, by acting as anti-cancer, antioxidant, and anti-inflammatory agents. Glycosylation increases stability, bioactivity, and solubility of compounds and improves their pharmacologi...

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Published in	International journal of biological macromolecules Vol. 163; pp. 1323 - 1332
Main Authors	Pourakbari, Ramin, Taher, Sanaz Mansouri, Mosayyebi, Bashir, Ayoubi-Joshaghani, Mohammad Hosein, Ahmadi, Hamid, Aghebati-Maleki, Leili
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 15.11.2020
Subjects	Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Cardiac glycoside Cardiac Glycosides - chemistry Cardiac Glycosides - pharmacology ErbB Receptors - antagonists & inhibitors ErbB Receptors - chemistry Flavonoid glycoside Flavonoids - chemistry Flavonoids - pharmacology Glycosides - chemistry Glycosides - pharmacology Glycosylated compounds Glycosylation Humans Plant Extracts - chemistry Plant Extracts - pharmacology Plants - chemistry Plants - metabolism Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Secondary Metabolism Flavonoid glycoside Cardiac glycoside Glycosylated compounds
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Abstract	Glycosylated compounds are major secondary metabolites of plants, which have various therapeutic effects on human diseases, by acting as anti-cancer, antioxidant, and anti-inflammatory agents. Glycosylation increases stability, bioactivity, and solubility of compounds and improves their pharmacological properties. Two well-known examples of glycosylated compounds include cardiac and flavonoid, the anti-tumor activities of which have been emphasized by several studies. However, little is known about their role in the treatment or prevention of cancer. In this review, recent studies on anti-tumor properties of cardiac and flavonoid glycosides, and their mechanisms of action, have been investigated. More specifically, this review is aimed at focusing on the multifactorial properties of cardiac and flavonoid compounds as well as their correlation with signaling pathways in the treatment of cancer.
AbstractList	Glycosylated compounds are major secondary metabolites of plants, which have various therapeutic effects on human diseases, by acting as anti-cancer, antioxidant, and anti-inflammatory agents. Glycosylation increases stability, bioactivity, and solubility of compounds and improves their pharmacological properties. Two well-known examples of glycosylated compounds include cardiac and flavonoid, the anti-tumor activities of which have been emphasized by several studies. However, little is known about their role in the treatment or prevention of cancer. In this review, recent studies on anti-tumor properties of cardiac and flavonoid glycosides, and their mechanisms of action, have been investigated. More specifically, this review is aimed at focusing on the multifactorial properties of cardiac and flavonoid compounds as well as their correlation with signaling pathways in the treatment of cancer.
Author	Pourakbari, Ramin Mosayyebi, Bashir Taher, Sanaz Mansouri Ayoubi-Joshaghani, Mohammad Hosein Ahmadi, Hamid Aghebati-Maleki, Leili
Author_xml	– sequence: 1 givenname: Ramin surname: Pourakbari fullname: Pourakbari, Ramin organization: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 2 givenname: Sanaz Mansouri surname: Taher fullname: Taher, Sanaz Mansouri organization: Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 3 givenname: Bashir surname: Mosayyebi fullname: Mosayyebi, Bashir organization: Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 4 givenname: Mohammad Hosein surname: Ayoubi-Joshaghani fullname: Ayoubi-Joshaghani, Mohammad Hosein organization: Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 5 givenname: Hamid surname: Ahmadi fullname: Ahmadi, Hamid organization: Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, Pécs University, Pécs, Hungary – sequence: 6 givenname: Leili surname: Aghebati-Maleki fullname: Aghebati-Maleki, Leili email: aghebatil@tbzmed.ac.ir organization: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords	Flavonoid glycoside Cardiac glycoside Glycosylated compounds
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Snippet	Glycosylated compounds are major secondary metabolites of plants, which have various therapeutic effects on human diseases, by acting as anti-cancer,...
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SubjectTerms	Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Cardiac glycoside Cardiac Glycosides - chemistry Cardiac Glycosides - pharmacology ErbB Receptors - antagonists & inhibitors ErbB Receptors - chemistry Flavonoid glycoside Flavonoids - chemistry Flavonoids - pharmacology Glycosides - chemistry Glycosides - pharmacology Glycosylated compounds Glycosylation Humans Plant Extracts - chemistry Plant Extracts - pharmacology Plants - chemistry Plants - metabolism Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Secondary Metabolism
Title	Implications for glycosylated compounds and their anti-cancer effects
URI	https://dx.doi.org/10.1016/j.ijbiomac.2020.06.281 https://www.ncbi.nlm.nih.gov/pubmed/32622770 https://search.proquest.com/docview/2420627035
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