Implications for glycosylated compounds and their anti-cancer effects

Glycosylated compounds are major secondary metabolites of plants, which have various therapeutic effects on human diseases, by acting as anti-cancer, antioxidant, and anti-inflammatory agents. Glycosylation increases stability, bioactivity, and solubility of compounds and improves their pharmacologi...

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Published inInternational journal of biological macromolecules Vol. 163; pp. 1323 - 1332
Main Authors Pourakbari, Ramin, Taher, Sanaz Mansouri, Mosayyebi, Bashir, Ayoubi-Joshaghani, Mohammad Hosein, Ahmadi, Hamid, Aghebati-Maleki, Leili
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.11.2020
Subjects
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Cardiac glycoside
Cardiac Glycosides - chemistry
Cardiac Glycosides - pharmacology
ErbB Receptors - antagonists & inhibitors
ErbB Receptors - chemistry
Flavonoid glycoside
Flavonoids - chemistry
Flavonoids - pharmacology
Glycosides - chemistry
Glycosides - pharmacology
Glycosylated compounds
Glycosylation
Humans
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plants - chemistry
Plants - metabolism
Protein Kinase Inhibitors - chemistry
Protein Kinase Inhibitors - pharmacology
Secondary Metabolism
Flavonoid glycoside
Cardiac glycoside
Glycosylated compounds
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Summary:Glycosylated compounds are major secondary metabolites of plants, which have various therapeutic effects on human diseases, by acting as anti-cancer, antioxidant, and anti-inflammatory agents. Glycosylation increases stability, bioactivity, and solubility of compounds and improves their pharmacological properties. Two well-known examples of glycosylated compounds include cardiac and flavonoid, the anti-tumor activities of which have been emphasized by several studies. However, little is known about their role in the treatment or prevention of cancer. In this review, recent studies on anti-tumor properties of cardiac and flavonoid glycosides, and their mechanisms of action, have been investigated. More specifically, this review is aimed at focusing on the multifactorial properties of cardiac and flavonoid compounds as well as their correlation with signaling pathways in the treatment of cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2020.06.281