Prevalence, risk factors and parental perceptions of gastroesophageal reflux disease in Asian infants in Singapore

• Published in: Annals of the Academy of Medicine, Singapore Vol. 51; no. 5; pp. 263 - 271
• Main Authors: McLoughlin, Vanessa Z Y, Suaini, Noor H A, Siah, Kewin, Loo, Evelyn X L, Pang, Wei Wei, Chong, Yap Seng, Godfrey, Keith M, Tan, Kok Hian, Chan, Jerry K Y, Goh, Anne E N, Lee, Bee Wah, Shek, Lynette P, Eriksson, Johan G, Aw, Marion M, Tham, Elizabeth H
• Format: Journal Article
• Language: English
• Published: Singapore 01.05.2022
• ISSN: 0304-4602; 0304-4602
• DOI: 10.47102/annals-acadmedsg.2021411

Infant gastroesophageal reflux disease (GERD) is a significant cause of concern to parents. This study seeks to describe GERD prevalence in infants, evaluate possible risk factors and assess common beliefs influencing management of GERD among Asian parents. Mother-infant dyads in the Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO) cohort were prospectively followed from preconception to 12 months post-delivery. GERD diagnosis was ascertained through the revised Infant Gastroesophageal Reflux Questionnaire (I-GERQ-R) administered at 4 time points during infancy. Data on parental perceptions and lifestyle modifications were also collected. The prevalence of infant GERD peaked at 26.5% at age 6 weeks, decreasing to 1.1% by 12 months. Infants exclusively breastfed at 3 weeks of life had reduced odds of GERD by 1 year (adjusted odds ratio 0.43, 95% confidence interval 0.19-0.97, =0.04). Elimination of "cold or heaty food" and "gas producing" vegetables, massaging the infant's abdomen and application of medicated oil to the infant's abdomen were quoted as major lifestyle modifications in response to GERD symptoms. Prevalence of GERD in infants is highest in the first 3 months of life, and the majority outgrow it by 1 year of age. Infants exclusively breastfed at 3 weeks had reduced odds of GERD. Cultural-based changes such as elimination of "heaty or cold" food influence parental perceptions in GERD, which are unique to the Asian population. Understanding the cultural basis for parental perceptions and health-seeking behaviours is crucial in tailoring patient education appropriately for optimal management of infant GERD.