Biocompatible, drug-loaded anti-adhesion barrier using visible-light curable furfuryl gelatin derivative

• Published in: International journal of biological macromolecules Vol. 120; no. Pt A; pp. 915 - 920
• Main Authors: Kim, Eun-Hye, Kim, Jae-Won, Han, Ga-Dug, Noh, Seung-Hyun, Choi, Jae-Hee, Choi, ChangSun, Kim, Mi-Kyung, Nah, Jae-Woon, Kim, Tae-Yeon, Ito, Yoshihiro, Son, Tae-Il
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2018
• Subjects: Anti-adhesion; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Cell Adhesion - drug effects; Cell Adhesion - radiation effects; Drug Carriers - chemistry; Drug Carriers - pharmacology; Drug Carriers - radiation effects; Drug-immobilization; Gelatin; Gelatin - chemistry; Gelatin - pharmacology; Humans; Inflammation - drug therapy; Light; Photo-curing; Riboflavin; Riboflavin - chemistry; Rose Bengal - chemistry; Rose Bengal - radiation effects; Visible-light; Riboflavin; Drug-immobilization; Photo-curing; Visible-light; Gelatin; Anti-adhesion
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2018.07.180

Recently, many of studies have been attempted to determine how to decrease adhesion. To effectively prevent adhesion, decrease in unnecessary surgical procedures, prevention of contact with other tissue, and drug treatment for inflammation are required. However, current anti-adhesion materials have disadvantages. To solve current problems, we prepared a biocompatible drug-loaded anti-adhesion barrier using a visible-light curable furfuryl gelatin derivative. We used riboflavin as a photo-initiator in the photo-curing process. The biocompatibility of riboflavin was estimated compared with that of Rose Bengal. In addition, the curing ratio was measured to determine whether riboflavin initiated photo-curing. We also evaluated the curing ratio of riboflavin according to the concentration of F-gelatin and the photo-irradiation time. A drug used to decrease inflammation that causes adhesion should not disappear from the surgical site and should also be released consistently. For this, we observed the release profiles of photo-immobilized ibuprofen with different concentrations of F-gelatin. Because an anti-adhesion barrier should protect from bacterial infection we evaluated the protective ability of a barrier formed by F-gelatin. In conclusion, a drug-loaded anti-adhesion barrier was prepared using a visible-light curable furfuryl gelatin derivative, with riboflavin as a photo-initiator. We expect that this drug-loaded anti-adhesion barrier effectively decrease adhesion formation. •Riboflavin showed the better photo-curable property and biocompatibility as photo-initiator than Rose Bengal.•As concentration of furfuryl gelatin and photo-irradiation time increase, the photo-curing ratio increase.•Release profile of photo-immobilized ibuprofen can be controlled by changing the concentration of furfuryl gelatin.•Surgical site can be protected from bacterial infection by furfuryl gelatin barrier and adhesion also can be decreased.•Drug-loaded anti-adhesion barrier can protect surgical site and prevent inflammation.