Novel multitopic diphos-type ligands

Seven novel imidazole and thiazole derivatives of diphos-type ligands are presented. They are of the general structure R 2P(CH 2) 2PR 2, where R is imidazol-2-yl ( 1), 1-methylimidazol-2-yl ( 2), 1-methylbenzimidazol-2-yl ( 3), 1-methylimidazol-5-yl ( 4), 2-isopropylimidazol-4(5)-yl ( 5), thiazol-2-...

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Bibliographic Details
Published inJournal of organometallic chemistry Vol. 695; no. 15; pp. 1891 - 1897
Main Authors Kunz, Peter C., Wetzel, Corinna, Bongartz, Melanie, Noffke, Anna Louisa, Spingler, Bernhard
Format Journal Article
LanguageEnglish
Published LAUSANNE Elsevier B.V 01.07.2010
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Imidazoles
Nitrogen heterocycles
Phosphane ligands
Physical Sciences
Science & Technology
Thiazoles
Imidazoles
Nitrogen heterocycles
Phosphane ligands
Thiazoles
CRYSTAL-STRUCTURE
COMPLEXES
BIDENTATE 2
GOLD(I) CHLORIDE ADDUCTS
ANTITUMOR-ACTIVITY
4-PYRIDYL PHOSPHINES
FUNCTIONALIZED DIPHOSPHINE
NITROGEN
1,2-BIS(DIPHENYLPHOSPHINO)ETHANE
BINDING
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Summary:Seven novel imidazole and thiazole derivatives of diphos-type ligands are presented. They are of the general structure R 2P(CH 2) 2PR 2, where R is imidazol-2-yl ( 1), 1-methylimidazol-2-yl ( 2), 1-methylbenzimidazol-2-yl ( 3), 1-methylimidazol-5-yl ( 4), 2-isopropylimidazol-4(5)-yl ( 5), thiazol-2-yl ( 6), benzothiazol-2-yl ( 7), thiazol-4-yl ( 8) or thiazol-5-yl ( 9). Syntheses involved direct metallation or halogen–metal exchange reactions. Their solubility, especially in aqueous solution, is strongly dependent on the nature of the substituents as is their partition coefficient log D. The crystal structures of compounds 2, 3, 7a and 9 as well as the structure of the rhodium complex [( 2) 2Rh 2Cl 2]Cl 2 ( 10) have been determined. [Display omitted]
ISSN:0022-328X
1872-8561
DOI:10.1016/j.jorganchem.2010.04.028