The Effect of Postinjury Kindled Seizures on Cognitive Performance of Traumatically Brain-Injured Rats

• Published in: Experimental neurology Vol. 136; no. 2; pp. 143 - 148
• Main Authors: Hamm, Robert J., Pike, Brian R., Temple, Meredith D., O'Dell, Dianne M., Lyeth, Bruce G.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.12.1995; Elsevier
• Subjects: Animals; Behavior, Animal; Biological and medical sciences; Brain Injuries - physiopathology; Cognition - physiology; Injuries of the nervous system and the skull. Diseases due to physical agents; Kindling, Neurologic - physiology; Male; Maze Learning; Medical sciences; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures - physiopathology; Task Performance and Analysis; Time Factors; Traumas. Diseases due to physical agents; Nervous system diseases; Rat; Kindling; Craniocerebral; Epilepsy; Rodentia; Diseases of the osteoarticular system; Cognition; Trauma; Cerebral disorder; Vertebrata; Mammalia; Animal; Central nervous system disease; Skull disease; Complication
• ISSN: 0014-4886; 1090-2430
• DOI: 10.1006/exnr.1995.1091

The purpose of this experiment was to examine the consequences of postinjury seizures on cognitive performance after experimental traumatic brain injury (TBI). Rats either were injured at a moderate (2.1 atm) level of central fluid percussion TBI ( n = 16) or were surgically prepared but did not receive a fluid pulse (sham-injured control, n = 16). Beginning 24 h after TBI, injured animals were injected (ip) once daily (Days 1-24 postinjury) with either saline ( n = 8) or 25 mg/kg pentylenetetrazol (PTZ) ( n = 8). Sham-injured rats were injected with an equal volume of saline ( n = 8) or PTZ ( n = 8). In both injured and sham-injured animals, daily injections of PTZ resulted in an increase in the severity of behavioral seizures over days. On Days 25-29 after injury or sham injury, all animals were tested in the Morris water maze (MWM). Analysis of maze performance indicated that in sham-injured animals PTZ-produced seizures had a detrimental effect on performance. In injured animals, however, PTZ-treated animals exhibited significantly faster acquisition and better terminal performance in the MWM than did untreated injured animals. These results show that posttraumatic kindled seizures do not exacerbate behavioral deficits after TBI and may, in fact, improve recovery following injury. The findings of this experiment are consistent with the hypothesis that post-TBI neuronal depression may contribute to behavioral morbidity following injury.