Cationic polymers and their therapeutic potential
The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent...
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| Published in | Chemical Society reviews Vol. 41; no. 21; pp. 7147 - 7194 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
08.10.2012
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| Subjects | |
| Online Access | Get full text |
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| Summary: | The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications. An overview of the synthesis and preparation of cationic polymers is provided along with their inherent bioactive and intrinsic therapeutic potential. In addition, cationic polymer based biomedical materials are covered. Major progress in the fields of drug and gene delivery as well as tissue engineering applications is summarized in the present review.
An overview of the inherent bioactive properties, architectures and therapeutic applications of cationic polymers. |
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| Bibliography: | Sangram Keshari Samal received his PhD degree in Biomaterials from the School of Biomolecular Science, University of Pisa, Italy. During his PhD, he was a visiting fellow at BWH, HST-MIT and Tufts University, USA. He undertook his first post-doctoral research on magnetic biomaterials for bone regeneration at Consiglio Nazionale delle Ricerche, Bologna, Italy. At present he is a post-doctoral fellow at the Polymer Chemistry & Biomaterials Group, Department of Organic Chemistry, University of Ghent, Belgium. His research interest is mainly focused on functionalization of polymers and evaluation of their potential for various therapeutic applications. Emo Chiellini is a former Professor of Fundamentals of Chemical Technology, Faculty of Engineering, University of Pisa, Italy. Presently he is acting as free-of-charge Director of the BIOlab of the Department of Chemistry & Industrial Chemistry of the University of Pisa. He has been involved in numerous projects funded by EC and industries in the field of Polymer Science and Technology. During his almost 50 years of activity he has collected more than 480 publications, edited and co-edited 20 books, issued 30 patents and delivered 260 speeches in national, international conferences, scientific institutions and industries. Lorenzo Moroni received his PhD in 2006 at University of Twente on 3D scaffold technologies for tissue engineering. After working at Johns Hopkins University on hydrogels and stem cells, in 2008 he was appointed the R&D director of the Musculoskeletal Tissue Bank of Rizzoli Orthopaedic Institute. Here, he investigated stem cells from alternative sources for cell banking and developed novel bioactive scaffolds for musculoskeletal regeneration. He joined again the Tissue Regeneration Department at University of Twente in 2009 as an assistant professor. Currently, his research interests aim at generating new libraries of bioactive scaffolds to recruit and deliver stem cells in situ, and control their fate. Peter Dubruel is currently heading a group of over 30 people and has published over 70 A1 papers. Since the start of 2006, he has been involved in several EU projects (3 FP6 and 4 FP7, 1 as a coordinator). Since end 2006, he has delivered over 20 invited lectures. He has been the spokesperson of the Young Scientist Forum (YSF) from the European Society for Biomaterials (ESB) for more than 5 years. He is part of the editorial team of BIOMAT.net and the journal Biomaterials. In 2010 and 2012, he was awarded, respectively, the YSF Excellence Award from the Romanian Society for Biomaterials and the Jean Leray Award from the ESB. David Kaplan is the Stern Family Professor of Engineering at Tufts University. He is Professor and Chair of the Department of Biomedical Engineering and also holds faculty appointments in the School of Medicine, Department of Chemistry and the Department of Chemical and Biological Engineering. His research focus is on biopolymer engineering to understand structure-function relationships, with emphasis on studies related to self-assembly, biomaterials engineering and functional tissue engineering. He has published over 500 papers and edited eight books. Clemens A. van Blitterswijk received his PhD in 1985 at Leiden University on artificial ceramic middle ear implants, for which he was awarded the Jean Leray award, the Marie Parijs award and the Klein award in the following years. He continued his research on bone and cartilage replacement, with extensions to muscle and skin substitutions. Today most of his research deals with regenerative medicine. Prof. van Blitterswijk has authored and co-authored more than 230 scientific papers and frequently acts as an invited speaker or chairman at international conferences in the field. For his more recent work, he received the George Winter award of the European society for Biomaterials and was appointed Fellow of Biomaterials Science and Engineering and member of the Royal Dutch Academy of Science. Sandra Van Vlierberghe finalized her PhD entitled 'Cell-Interactive Biopolymer-based Hydrogels designed for Tissue Engineering' in 2008 in the Polymer Chemistry & Biomaterials Group at Ghent University. At present, she is working as a senior post-doctoral fellow at the same institution, supported by the Research Foundation Flanders (FWO-Flanders). She has published more than 50 papers and is a promoter of 5 PhD students. In addition, Dr Van Vlierberghe is Editorial Board Member of BIOMAT.net, responsible for the book section and Executive Board Member of the Young Scientist Forum, which is affiliated to the European Society for Biomaterials. Her research interests are related to the development and modification of polymers for biomedical applications. Mamoni Dash received her PhD (2010) degree in Biomaterials from the University of Pisa, Italy. She undertook post-doctoral research firstly (2010-2011) in the research group of Professor Emo Chiellini, BIOLab, University of Pisa, Italy, and subsequently (2011-Present) at the Department of Organic Chemistry, University of Ghent, Belgium, in the research group of Professor Peter Dubruel. Her research interest lies in the interdisciplinary area of polymers, and currently focuses on the development of polymers as biomaterials for biomedical applications. 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| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/c2cs35094g |