Host-guest drug delivery by β-cyclodextrin assisted polysaccharide vehicles: A review

• Published in: International journal of biological macromolecules Vol. 240; p. 124338
• Main Authors: Sahu, Krishna Manjari, Patra, Swapnita, Swain, Sarat K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.06.2023
• Subjects: beta-Cyclodextrins - chemistry; Cyclodextrins; Drug delivery; Drug Delivery Systems; Excipients; Host-guest; Inclusion complex; Polysaccharide; Polysaccharides; Solubility; β-Cyclodextrin; BJH; CDHA; CM-β-CD/ cmβCD; ALG/Alg/A/Al; MSN-SS-N=C-HA; HD-PEG; β-Cyclodextrin; CMC; GMA; IC; CFCD; CMD; Dx-CD-FA; Dex/Dx; AA; CUR; POA; MALDI-TOF; CMC1; IR; DOX; RSM; Fc-PLA; MSN-SS-N=C-Ph; GEL; TGA; SMP; HPC; SEM; TEMPO; Polysaccharide; BA; NMCS; GG1; FITC; GG2; HPβCD/ HPCD; CMCD; FTIR; ESI; XPS; HPLC; PNIPAAM; SS; FTIR-ATR; SFS; NMA; SPIO; MSN; CN; Cat- β-CD; CP; WAXS; BET; PAA; NMR; DM- β-CD; UV–Vis; MSN-SS-NH2; PAH; PLCD; 5-FU; GPTMS; PSCD; DRS; β-TC/ β-CyD; XRD; pHEMA; CHX; AMCD; SPR; CSIC; DSC; EDX; SCD2; CLSM; Inclusion complex; ROESY; FA-CMC-C12; TPECD; Dex-mal; NF; PCL; FA; HPMC; PCS; NP; CBD; PLA; BM-PCL; AFM; CS/CH/Chi; HHDDP; DLS; LDC; Drug delivery; MFC; MNP; SBE; PDM; dextran-MA; HCPT NP; L-β-CD; PMA; DSPEG; FESEM; GO; GCD; Host-guest; TMC; CMC-Azo; XG; CD1; APB; PEG; MGO; TONFC; Nag; SCD; ESEM; HA; PVA; HAAD; TEM; CA-CD
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2023.124338

Among different forms of cyclodextrin (CD), β-CD has been taken a special attraction in pharmaceutical science due to lowest aqueous solubility and adequate cavity size. β-CD forms inclusion complex with drugs in combination with biopolymers such as polysaccharides which plays a vital role as a vehicle for safe release of drugs. It is noticed that, β-CD assisted polysaccharide-based composite achieves better drug release rate through host-guest mechanism. Present review is a critical analysis of this host-guest mechanism for release of drugs from polysaccharide supported β-CD inclusion complex. Various important polysaccharides such as cellulose, alginate, chitosan, dextran, etc. and their association with β-CD in relevant to drug delivery are logically compared in present review. Efficacy of mechanism of drug delivery by different polysaccharides with β-CD is analytically examined in schematic form. Drug release capacity at different pH conditions, mode of drug release, along with characterization techniques adopted by individual polysaccharide-based CD complexes are comparatively established in tabular form. This review may explore better visibility for researchers those are working in the area of controlled release of drugs by carrier consist of β-CD associated polysaccharide composite through host-guest mechanism. [Display omitted] •The formation of inclusion complex of β-CD with drug is explained in pictorial representation.•Chemical interactions of polysaccharide with β-CD are schematically established.•Advantages of host-guest mechanism are compared with conventional drug release techniques.•Drug encapsulation efficiency and release percentages are critically analysed.