Bilateral somatosensory cortex disinhibition in complex regional pain syndrome type I

• Published in: Neurology Vol. 77; no. 11; p. 1096
• Main Authors: Lenz, M, Höffken, O, Stude, P, Lissek, S, Schwenkreis, P, Reinersmann, A, Frettlöh, J, Richter, H, Tegenthoff, M, Maier, C
• Format: Journal Article
• Language: English
• Published: United States 13.09.2011
• Subjects: Adult; Aged; Electric Stimulation - methods; Evoked Potentials, Somatosensory - physiology; Female; Humans; Male; Middle Aged; Neural Inhibition - physiology; Reflex Sympathetic Dystrophy - diagnosis; Reflex Sympathetic Dystrophy - physiopathology; Somatosensory Cortex - physiopathology; Young Adult
• ISSN: 1526-632X
• DOI: 10.1212/WNL.0b013e31822e1436

In a previous study, we found bilateral disinhibition in the motor cortex of patients with complex regional pain syndrome (CRPS). This finding suggests a complex dysfunction of central motor-sensory circuits. The aim of our present study was to assess possible bilateral excitability changes in the somatosensory system of patients with CRPS. We measured paired-pulse suppression of somatosensory evoked potentials in 21 patients with unilateral CRPS I involving the hand. Eleven patients with upper limb pain of non-neuropathic origin and 21 healthy subjects served as controls. Innocuous paired-pulse stimulation of the median nerve was either performed at the affected and the unaffected hand, or at the dominant hand of healthy controls, respectively. We found a significant reduction of paired-pulse suppression in both sides of patients with CRPS, compared with control patients and healthy control subjects. These findings resemble our findings in the motor system and strongly support the hypothesis of a bilateral complex impairment of central motor-sensory circuits in CRPS I.