A magnetic mesoporous silica nanoparticle-based drug delivery system for photosensitive cooperative treatment of cancer with a mesopore-capping agent and mesopore-loaded drug

• Published in: Nanoscale Vol. 5; no. 4; pp. 1544 - 1551
• Main Authors: Kne evi, Nikola, Lin, Victor S.-Y
• Format: Journal Article
• Language: English
• Published: England 21.02.2013
• Subjects: Animals; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - chemistry; Cadmium sulfides; Camptothecin - administration & dosage; Camptothecin - chemistry; Cancer; CHO Cells; Combined Modality Therapy; Cricetinae; Cricetulus; Drug delivery systems; Drugs; Magnetic Fields; Materials Testing; Nanocapsules - administration & dosage; Nanocapsules - chemistry; Nanoparticles; Nanostructure; Neoplasms, Experimental - pathology; Neoplasms, Experimental - therapy; Photosensitivity; Phototherapy - methods; Porosity; Silicon Dioxide - chemistry; Viability
• ISSN: 2040-3364; 2040-3372
• DOI: 10.1039/c2nr33417h

Lately, there has been a growing interest in anticancer therapy with a combination of different drugs that work by different mechanisms of action, which decreases the possibility that resistant cancer cells will develop. Herein we report on the development of a drug delivery system for photosensitive delivery of a known anticancer drug camptothecin along with cytotoxic cadmium sulfide nanoparticles from a magnetic drug nanocarrier. Core-shell nanoparticles consisting of magnetic iron-oxide-cores and mesoporous silica shells are synthesized with a high surface area (859 m 2 g −1 ) and hexagonal packing of mesopores, which are 2.6 nm in diameter. The mesopores are loaded with anticancer drug camptothecin while entrances of the mesopores are blocked with 2-nitro-5-mercaptobenzyl alcohol functionalized CdS nanoparticles through a photocleavable carbamate linkage. Camptothecin release from this magnetic drug delivery system is successfully triggered upon irradiation with UV light, as measured by fluorescence spectroscopy. Photosensitive anticancer activity of the drug delivery system is monitored by viability studies on Chinese hamster ovarian cells. The treatment of cancer cells with drug loaded magnetic material leads to a decrease in viability of the cells due to the activity of capping CdS nanoparticles. Upon exposure to low power UV light (365 nm) the loaded camptothecin is released which induces additional decrease in viability of CHO cells. Hence, the capping CdS nanoparticles and loaded camptothecin exert a cooperative anticancer activity. Responsiveness to light irradiation and magnetic activity of the nanocarrier enable its potential application for selective targeted treatment of cancer. The cooperative anticancer effect of mesopore-loaded camptothecin and mesopore-capping CdS nanoparticles was observed under UV irradiation of cancer cells treated with a magnetic mesoporous silica nanoparticles-based photosensitive drug carrier.