Preparation and application of a polymer with pH/temperature-responsive targeting

• Published in: International journal of biological macromolecules Vol. 165; no. Pt A; pp. 995 - 1001
• Main Authors: Kou, Zongliang, Dou, Detian, Mo, Huiqun, Ji, Jianyan, Lan, Lihong, Lan, Xiongdiao, Zhang, Jinyan, Lan, Ping
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.12.2020
• Subjects: Biological Availability; Drug carrier; Drug Carriers - chemical synthesis; Drug Carriers - chemistry; Drug Carriers - therapeutic use; Drug Delivery Systems; Drug Liberation; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions - drug effects; Micelles; Nanoparticles - chemistry; Nanoparticles - therapeutic use; Particle Size; Polyethylene Glycols - chemistry; Polymer; Polymers - chemical synthesis; Polymers - chemistry; Polymers - therapeutic use; Temperature; Drug carrier; Polymer; Micelles
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2020.09.248

Targeted drug carrier systems not only prolong the long-term circulation of drugs, but also improve their bioavailability. To obtain a pH/temperature synergistically responsive polymer carrier, temperature and pH-sensitive groups were chemically grafted onto a cassava starch backbone. Secondly, the structure of the polymer micelle carrier was characterized, and finally the drug loading performance and capacity of the drug carrier were explored. It was observed that cumulative drug release was low when the temperature and pH values met one of two conditions. Only at a high temperature and low pH (T = 38 °C, pH = 5.5, as in tumor tissue) did cumulative drug release reach its maximum value. The design of the polymer carrier described in the present study represents a novel paradigm in precision release drug carriers.