Effect of Chronic Oral Pentoxifylline Administration on Murine Erythrocyte Deformability

• Published in: The Journal of surgical research Vol. 63; no. 2; pp. 387 - 392
• Main Authors: Johnson, Frank E., Tolman, Kym C., Farr, Susan A., Mawad, Maurice R., Raju, Padma I., Hueneburg, Lalita R., Sutera, Salvatore P.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.1996; Elsevier
• Subjects: Administration, Oral; Animals; Biological and medical sciences; Cardiovascular system; Equipment Design; Erythrocyte Deformability - drug effects; Male; Medical sciences; Mice - blood; Mice, Inbred Strains; Pentoxifylline - pharmacology; Pharmacology. Drug treatments; Reference Values; Rheology - instrumentation; Time Factors; Vasodilator agents. Cerebral vasodilators; Deformability; Vasodilator agent; Rodentia; Red blood cell; Pharmacology; Experimental study; Vertebrata; Chemotherapy; Chronic; Mammalia; Mouse; Animal; Clinical investigation; Circulatory system; Biological effect; Rheometer
• ISSN: 0022-4804; 1095-8673
• DOI: 10.1006/jsre.1996.0281

Background: Pentoxifylline has been reported to increase radiation sensitivityin vivo.We sought to evaluate whether this effect is mediated by changes in murine erythrocyte flexibility. Methods: Pentoxifylline was administered via liquid or solid diet to young adult male CF-1 mice for 1–6 weeks. After 1, 3, and 6 weeks of drug administration, plasma levels of pentoxifylline and major derivatives were measured and erythrocyte deformability was assessed by rheoscopy, a technique which permits direct measurement of individual cellular dimensions. Results: Contrary to prior reports, we found no discernible effect of the drug on erythrocyte deformability. Conclusions: The beneficial effect of pentoxifylline administration on radiation sensitivity in tumor-bearing mice is mediated by other mechanisms.