Comparative evaluation for controlling release of niacin from protein- and cellulose-chitosan based hydrogels

• Published in: International journal of biological macromolecules Vol. 150; pp. 228 - 237
• Main Authors: Hanna, Demiana H., Lotfy, Vivian F., Basta, Altaf H., Saad, Gamal R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2020
• Subjects: Cellulose - chemistry; Cellulose-chitosan based hydrogel; Chitosan - chemistry; Cytotoxicity; Drug Carriers - chemistry; Drug Compounding; Drug Delivery Systems; Drug Liberation; Encapsulation efficiency; Hydrogels - chemistry; Hydrogen-Ion Concentration; In-vitro niacin release; Kinetics; Niacin - administration & dosage; Niacin - pharmacokinetics; Niacin drug; Protein-chitosan based hydrogel; Proteins - chemistry; Spectroscopy, Fourier Transform Infrared; Encapsulation efficiency; Cellulose-chitosan based hydrogel; Cytotoxicity; Niacin drug; Protein-chitosan based hydrogel; In-vitro niacin release
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2020.02.056

This work deals with assessing the efficient performance of sodium caseinate (SC) as protein-based drug delivery system of niacin (NA) than carboxymethyl cellulose (CMC). In this respect the hydrogels from complexation of chitosan with sodium caseinate (SC/Ch) or sodium carboxymethyl cellulose (CMC/Ch) were prepared. The Synthesized NA free and loaded hydrogels were characterized by many techniques for examining the interaction, morphology, swelling, encapsulation efficiency (EE) and loading (L) % of niacin, as well as cytotoxicity study. The finding data showed the promising behavior of SC/Ch hydrogel than CMC/Ch hydrogel, toward the amount of loaded NA (95.6%) and in vitro slow sustained release up to 24 h. Whereas, the entrapment efficiency of the CMC/Ch to nicotinic acid was reached 85.6%, and it possessed highly initial burst release followed by a slower release up to 24 h. At pH 7.4 (simulated intestinal fluid) both hydrogels provided higher level of releasing profile to NA than pH 2.1 (gastric fluid). The NA release from hydrogels followed Fickian and non-Fickian diffusion mechanism according to pH 7.4 and 2.1, respectively. It is interesting to note that, the data obtained are higher than those obtained from literature reported hydrogel, e.g., poly (2-hydroxyethyl methacrylate). Neutral red uptake and lactate dehydrogenase assays confirmed both hydrogels have good biocompatibility and could be used as nontoxic drug delivery system. So, we recommended SC/Ch hydrogel as an effective controlled niacin drug delivery system with reducing systemic side effects and improved intestinal targeting efficiency. •Assessment of protein- and cellulose-chitosan hydrogels as drug delivery systems•Effective of sodium caseinate–chitosan hydrogel for slow release of niacin drug•Mechanisms of diffusion and erosion coexisted for the release control of niacin.•The SC/Ch hydrogel possessed interesting feature for reducing systemic side effects.•The SC/Ch hydrogel provided improvement in intestinal targeting efficiency.