Oral versus topical Ibuprofen for chronic knee pain: a prospective randomized pilot study
Topical ibuprofen provides an alternative treatment to oral ibuprofen for the treatment of chronic knee pain. To compare the efficacy of topical versus oral ibuprofen in chronic knee pain treatment. Prospective, randomized, unblinded pilot study. A private pain management practice. Twenty patients r...
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Published in | Pain physician Vol. 13; no. 5; pp. 457 - 467 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
American Society of Interventional Pain Physician
01.09.2010
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Subjects | |
Online Access | Get full text |
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Summary: | Topical ibuprofen provides an alternative treatment to oral ibuprofen for the treatment of chronic knee pain.
To compare the efficacy of topical versus oral ibuprofen in chronic knee pain treatment.
Prospective, randomized, unblinded pilot study.
A private pain management practice.
Twenty patients received either ibuprofen tablets 3 times daily (2400 mg total) or 4% topical gel 4 times daily (320 mg total) for 2 weeks. Subjects completed the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index, the Medical Outcomes Study 12-Item Short Form (SF-12v2) Health Survey, and a satisfaction questionnaire.
Comparison of WOMAC and SF-12v2 mean changes from baseline showed no differences between groups. Patient satisfaction and study treatment convenience were rated equivalently between groups. Within the topical group, significant improvements (P < 0.05) were experienced in the mean differences of WOMAC Pain scores from baseline to 2 weeks (-82.6, -158.3 to -6.8), WOMAC Stiffness scores from baseline to one week (-25.3, -50.0 to -0.6) and baseline to 2 weeks (-47.8, -95.7 to 0.1), WOMAC Physical Function scores from baseline to one week (-175.9, -348.6 to -3.2) and baseline to 2 weeks (-312.1, -580.5 to -43.7), and patient satisfaction scores from baseline to one week and baseline to 2 weeks. Within the oral group, significant improvements (P < 0.05) were experienced in mean differences of WOMAC Physical Function from baseline to one week (-342.6, -638.1 to -47.1) and baseline to 2 weeks (-323.2, -637.1 to -9.2).
As this was a preliminary investigation, the sample size of 20 subjects is a limitation in this study.
Treatment of chronic knee pain with topical ibuprofen provided comparable clinical efficacy and patient satisfaction as oral ibuprofen in this pilot study. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 1533-3159 2150-1149 |
DOI: | 10.36076/ppj.2010/13/457 |