Diagnostic Potential of 3D-Data–Based Reconstruction Software: An Analysis of the Rare Disease Pattern of Cherubism

• Published in: The Cleft palate-craniofacial journal Vol. 46; no. 2; pp. 215 - 219
• Main Authors: Holst, Alexandra Ioana, Hirschfelder, Ursula, Holst, Stefan
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.03.2009; American Cleft Palate-Craniofacial Association; SAGE PUBLICATIONS, INC
• Subjects: Absorptiometry, Photon; Bacteria; Biological and medical sciences; Bone Density; Cherubism - diagnostic imaging; Cherubism - genetics; Child; Cone-Beam Computed Tomography - methods; Dentistry; Diseases of the osteoarticular system; Female; Humans; Image Processing, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; Male; Malformations and congenital and or hereditary diseases involving bones. Joint deformations; Mandible - diagnostic imaging; Medical sciences; Otorhinolaryngology. Stomatology; Patient Care Planning; Software; Studies; Teeth; Three dimensional imaging; Tomography, X-Ray Computed - methods; Tooth Germ - diagnostic imaging; User-Computer Interface; computed tomography; treatment planning; cherubism; orthodontics; three-dimensional reconstruction; Radiodiagnosis; Cherubism; Stomatology; Diseases of the osteoarticular system; Anatomical reconstruction; Orthodontic procedures; Treatment; Surgery; Rare disease; Medical imagery; Software; Computerized axial tomography; Diagnosis; Osteochondrodysplasia; Treatment planning
• ISSN: 1055-6656; 1545-1569
• DOI: 10.1597/07-015.1

Cherubism is an autosomal-dominant syndrome characterized by bilateral maxillomandibular bony degeneration, fibrous connective tissue hyperplasia, and displacement of permanent tooth germs. Reossification of the cystic lumen occurs spontaneously, but dislocated teeth must be realigned orthodontically. Advancements in virtual 3D reconstruction of anatomic structures based on computed tomography (CT) or cone beam CT data have provided for more predictable individual treatment planning. We evaluated two software programs for making densitometry and volume measurements of cystic areas in the mandibles, and for 3D visualization of permanent tooth germs within the cystic lumen, in two siblings with cherubism.