Biodegradable dual stimuli responsive alginate based microgels for controlled agrochemicals release and soil remediation
To meet the growing food demand of increasing world population while reducing the harmful environmental effects of agrochemicals, development of smart nanoformulation is of prime importance. Herein, dual stimuli responsive alginate based microgels (OAlgDP MGs) (≈160 nm) are developed for controlled...
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Published in | International journal of biological macromolecules Vol. 228; pp. 323 - 332 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
15.02.2023
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Subjects | |
Online Access | Get full text |
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Summary: | To meet the growing food demand of increasing world population while reducing the harmful environmental effects of agrochemicals, development of smart nanoformulation is of prime importance. Herein, dual stimuli responsive alginate based microgels (OAlgDP MGs) (≈160 nm) are developed for controlled release of agrochemicals and soil remediation. These microgels are prepared using octyl amine functionalized alginate which is crosslinked by 3, 3′-dithiopropionohydrazide crosslinker providing both hydrazone and disulfide bonds in microgels network. OAlgDP MGs are further loaded with hydrophobic diuron herbicide displaying ≈85 % encapsulation efficiency. Sustained release of diuron is obtained in 2 mM GSH (≈100 % after 380 h) and at pH 5 (≈72 % after 240 h). Furthermore, OAlgDP MGs are nontoxic up to 150 μg/mL against HEK293T cells while their reduced form is capable of capturing the heavy metal ions (Cu2+ and Hg2+) showing the potential of the developed system for moving toward sustainable agriculture. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0141-8130 1879-0003 |
DOI: | 10.1016/j.ijbiomac.2022.12.225 |