Immature platelet dynamics in management of protracted response to therapy of a young pediatric patient with immune-mediated thrombotic thrombocytopenic purpura

•A-IPC on admission of pediatric iTTP patient was depressed as seen in adult patients (ADAMTS13 deficiency)•A-IPC on admission predicted ADAMTS13 deficiency and two-fold increase in A-IPC prior to PLT count change correlated with response to therapy•A-IPC instability indicated protracted response to...

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Bibliographic Details
Published inThrombosis research Vol. 228; pp. 145 - 147
Main Authors Maitta, Robert W., Reeves, Hollie M., Downes, Katharine A., He, Xiangrong, Hackney, Lisa R., Ahuja, Sanjay P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.08.2023
Subjects
Absolute immature platelet count
ADAMTS13 Protein
Blood Platelets
Child
Children
Humans
Pediatric
Plasma Exchange
Platelet Count
Platelets
Purpura, Thrombotic Thrombocytopenic - therapy
Therapeutic plasma exchange
Therapy
TTP
Therapy
TTP
Absolute immature platelet count
Therapeutic plasma exchange
Children
Platelets
Pediatric
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Summary:•A-IPC on admission of pediatric iTTP patient was depressed as seen in adult patients (ADAMTS13 deficiency)•A-IPC on admission predicted ADAMTS13 deficiency and two-fold increase in A-IPC prior to PLT count change correlated with response to therapy•A-IPC instability indicated protracted response to therapy similar but of longer duration to adult iTTP patients with high inhibitor•A-IPC and PLT count concomitantly decreased early in hospitalization but this was of lesser magnitude later on during presentation
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2023.06.002