Disruption of phospholipid metabolism by paraquat in cultured pneumocytes

Paraquat (PQ) has specific pneumotoxicity in humans. Its effects on phospholipid metabolism in type 2 pneumocytes, A-549, and in lung fibroblasts, WI-38, were examined. PQ inhibited the incorporation of palmitic acid into phosphatidyl-ethanolamine by 42%, but did not inhibit the incorporation into p...

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Bibliographic Details
Published inJournal of toxicology and environmental health Vol. 9; no. 4; p. 527
Main Authors Saito, K, Parker, W.B, Menzel, D.B
Format Journal Article
LanguageEnglish
Published United States 01.04.1982
Subjects
Cells, Cultured
Humans
Lung - cytology
Lung - drug effects
Lung - metabolism
Palmitic Acid
Palmitic Acids - metabolism
Paraquat - pharmacology
Phosphatidylcholines - biosynthesis
Phosphatidylethanolamines - biosynthesis
Phospholipids - biosynthesis
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Summary:Paraquat (PQ) has specific pneumotoxicity in humans. Its effects on phospholipid metabolism in type 2 pneumocytes, A-549, and in lung fibroblasts, WI-38, were examined. PQ inhibited the incorporation of palmitic acid into phosphatidyl-ethanolamine by 42%, but did not inhibit the incorporation into phosphatidylcholine. PQ also inhibited the incorporation of acetate into phosphatidylcholine and ethanolamine by 82-88% in A-549 cells and by 92% in WI-38 cells. PQ inhibited the incorporation of choline into phosphatidylcholine and ethanolamine by 55 and 73%, respectively. Phosphatidylcholine was detected in the medium of A-549 cells. PQ completely inhibited this phosphatidylcholine secretion. These results suggest that PQ has inhibitory effects on phospholipid synthesis and excretion in human type 2 pneumocytes.
Bibliography:H00
8236500
ISSN:0098-4108
1087-2620
DOI:10.1080/15287398209530185