Carbon nanosphere based bifunctional oxidoreductase nano-catalytic agent to mitigate hypoxia in cancer cells
Developing metal-free carbon nanozyme for tumor hypoxia is difficult. In biomedical applications, especially in the case of biomolecular detection, extensive research has been done on nanozymes with enzyme-mimicking catalytic activity. However, there are considerably fewer investigations on targeted...
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| Published in | International journal of biological macromolecules Vol. 233; p. 123466 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.04.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Developing metal-free carbon nanozyme for tumor hypoxia is difficult. In biomedical applications, especially in the case of biomolecular detection, extensive research has been done on nanozymes with enzyme-mimicking catalytic activity. However, there are considerably fewer investigations on targeted nano-catalytic tumor therapy. Nano catalytic medicine-enabled chemotherapy is a safe and promising treatment strategy that involves the conversion of excess H2O2 into O2 in a tumor environment. Here we have synthesized carbon nanosphere (CNS) using the Camellia sinensis plant (CS-CNS). Further surface functionalization was achieved via nitrilotriacetic acid conjugation (NTA@CS-CNS). A stability study of synthesized nanozyme in the presence of various cations, anions, and 5 different pH range suggested the robustness of carbon based nanoassembly. The catalytic in vitro study shows that NTA@CS-CNS mimics peroxidase and catalase using TMB and H2O2 as substrates. NTA@CS-CNS showed Km and Vmax values of ~ 193.2 μM and 0.43 μM/s, ~ 413 μM and 1.42 μM/s, and ~ 378 μM and 1.63 μM/s, respectively when H2O2 and TMB was used for CAT and POD activity. Results showed that NTA@CS-CNS in combination with SFN and laser irradiation reduces hypoxia. Hence, our study could pave the path for the development of different non-toxic nano catalytic therapy for tumors in cancerous cells. |
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| AbstractList | Developing metal-free carbon nanozyme for tumor hypoxia is difficult. In biomedical applications, especially in the case of biomolecular detection, extensive research has been done on nanozymes with enzyme-mimicking catalytic activity. However, there are considerably fewer investigations on targeted nano-catalytic tumor therapy. Nano catalytic medicine-enabled chemotherapy is a safe and promising treatment strategy that involves the conversion of excess H
O
into O
in a tumor environment. Here we have synthesized carbon nanosphere (CNS) using the Camellia sinensis plant (CS-CNS). Further surface functionalization was achieved via nitrilotriacetic acid conjugation (NTA@CS-CNS). A stability study of synthesized nanozyme in the presence of various cations, anions, and 5 different pH range suggested the robustness of carbon based nanoassembly. The catalytic in vitro study shows that NTA@CS-CNS mimics peroxidase and catalase using TMB and H
O
as substrates. NTA@CS-CNS showed K
and V
values of ~ 193.2 μM and 0.43 μM/s, ~ 413 μM and 1.42 μM/s, and ~ 378 μM and 1.63 μM/s, respectively when H
O
and TMB was used for CAT and POD activity. Results showed that NTA@CS-CNS in combination with SFN and laser irradiation reduces hypoxia. Hence, our study could pave the path for the development of different non-toxic nano catalytic therapy for tumors in cancerous cells. Developing metal-free carbon nanozyme for tumor hypoxia is difficult. In biomedical applications, especially in the case of biomolecular detection, extensive research has been done on nanozymes with enzyme-mimicking catalytic activity. However, there are considerably fewer investigations on targeted nano-catalytic tumor therapy. Nano catalytic medicine-enabled chemotherapy is a safe and promising treatment strategy that involves the conversion of excess H2O2 into O2 in a tumor environment. Here we have synthesized carbon nanosphere (CNS) using the Camellia sinensis plant (CS-CNS). Further surface functionalization was achieved via nitrilotriacetic acid conjugation (NTA@CS-CNS). A stability study of synthesized nanozyme in the presence of various cations, anions, and 5 different pH range suggested the robustness of carbon based nanoassembly. The catalytic in vitro study shows that NTA@CS-CNS mimics peroxidase and catalase using TMB and H2O2 as substrates. NTA@CS-CNS showed Km and Vmax values of ~ 193.2 μM and 0.43 μM/s, ~ 413 μM and 1.42 μM/s, and ~ 378 μM and 1.63 μM/s, respectively when H2O2 and TMB was used for CAT and POD activity. Results showed that NTA@CS-CNS in combination with SFN and laser irradiation reduces hypoxia. Hence, our study could pave the path for the development of different non-toxic nano catalytic therapy for tumors in cancerous cells. |
| ArticleNumber | 123466 |
| Author | Acharya, Amitabha Shukla, Ashish K. Saini, Trilok Chand Randhawa, Shiwani |
| Author_xml | – sequence: 1 givenname: Ashish K. orcidid: 0000-0002-9905-9795 surname: Shukla fullname: Shukla, Ashish K. – sequence: 2 givenname: Shiwani orcidid: 0000-0001-7162-7490 surname: Randhawa fullname: Randhawa, Shiwani – sequence: 3 givenname: Trilok Chand orcidid: 0000-0003-4722-6990 surname: Saini fullname: Saini, Trilok Chand – sequence: 4 givenname: Amitabha orcidid: 0000-0002-9013-9027 surname: Acharya fullname: Acharya, Amitabha email: amitabha@ihbt.res.in |
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| Keywords | Carbon nanozyme Catalase and peroxidase activity Oxidative stress Hypoxia Nano catalytic medicine |
| Language | English |
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| SubjectTerms | Carbon - chemistry Carbon nanozyme Catalase and peroxidase activity Humans Hydrogen Peroxide - chemistry Hypoxia Nano catalytic medicine Nanospheres Neoplasms - drug therapy Oxidative stress |
| Title | Carbon nanosphere based bifunctional oxidoreductase nano-catalytic agent to mitigate hypoxia in cancer cells |
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