Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moieties

• Published in: Inorganica Chimica Acta Vol. 498; p. 119154
• Main Authors: Belveren, Samet, Poyraz, Samet, Pask, Christopher M., Ülger, Mahmut, Sansano, José M., Ali Döndaş, H.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.2019; Elsevier Science Ltd
• Subjects: Aminocarbothiol; Angles (geometry); Antibacterial; Antifungal; Crystals; Diffraction patterns; Fungicides; Pattern analysis; Platinum; Platinum complexes; Single crystals; Antifungal; Antibacterial; Aminocarbothiol; Platinum complexes
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2019.119154

Platinun complexes acting as antimicrobials. [Display omitted] •Antimicrobial platinum complexes: the effect of aroylaminocarbo-N-thioyl ligands. Platinum complexes, derived from two families of bidentate funcionalized aroylaminocarbo-N-thyoyl prolinates, are prepared using mild conditions from prolinates, which are available via 1,3-dipolar cycloadditions. The resulting four coordinated neutral square-planar platinum(II) complexes are very stable and are fully characterized. Their structures are determined by spectroscopic and analytical methods and one of them by single crystal X-ray diffraction analysis. In this pattern, the platinum exhibits distorted square planar geometry, with cis-bond angles ranging from 89.42(2) and 94.37(6)° and trans-bond angles of 176.19(6) and 177.08(6)°, respectively. Anti(myco)bacterial and antifungal studies of all these new compounds are carried out under standardized protocols.