Monte Carlo study of organ doses and related risk for cancer in Algeria from scattered neutrons in prostate treatment involving 3D-CRT

• Published in: Applied radiation and isotopes Vol. 180; p. 110065
• Main Authors: Alem-Bezoubiri, Asma, Suleiman, Suleiman Ameir, Behidj, Ikram, Mazrou, Hakim, Chami, Ahmed Chafik
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2022
• Subjects: 3D conformal radiotherapy; External beam radiotherapy; Monte Carlo study; Out-of-field dose; Prostate cancer; Secondary cancer risk; Monte Carlo study; External beam radiotherapy; Secondary cancer risk; 3D conformal radiotherapy; Prostate cancer; Out-of-field dose
• ISSN: 0969-8043; 1872-9800
• DOI: 10.1016/j.apradiso.2021.110065

The present study aimed to evaluate organ doses and related risk for cancer from scattered neutrons involving 3D Conformational Radiotherapy (3D−CRT) for patients with prostate cancer in Algeria based on Monte Carlo technique and to estimate the secondary cancer risks. To this purpose, a detailed geometric Monte Carlo (MC) modeling of the LINAC Varian 2100C combined with a computational whole-body phantom was carried out. The neutron equivalent doses were calculated in-field and out-of field of patient's organs using the phase-space method. The obtained neutron equivalent doses were used to estimate the Lifetime Attributable Risks (LARs) for cancer incidence in out of field organs. LARs was evaluated assuming Biological Effects of Ionizing Radiation VII (BEIR VII) risk model for exposure age in the range 35–70 years, according to the interval's age of treated patients in Algeria. The baselines cancer risks and survival data were associated with the statistical data for the Algerian population. The results showed that the neutrons equivalent doses per prescribed dose (Photon Dose) mostly depend on the distance of organs from the treated volume. The highest and lowest equivalent doses of 1.18 mSv/Gy and 0.25 mSv/Gy were recorded in the bladder and heart, respectively. The highest estimated lifetime attributable risk per 100,000 population was found for 35 yrs’ exposure age in colon 49.94, lung 16.63 and stomach 11.17. The lowest risks were found for 70 yrs’ age, in spine 0.06 and thyroid 0.14. The results showed that LARs values decrease with the increase of the exposure age and cancer incidence risk is lower than the baseline cancer risk incidence for all organs. The present study may help in providing a database on the impact of radiotherapy-induced secondary cancer incidence during 3D-CRT for prostate cancer in Algeria. •The detailed geometry of VARIAN 2100c LINAC head combined with a computational whole-body phantom was developed.•The treatment plan of prostate cancer following 3D-CRT procedure was considered.•The developed model was applied for calculating neutrons equivalent doses in organs.•The Lifetime Attributable Risks (LARs) for cancer incidence were estimated for different organs.•The Biological Effects of Ionizing Radiation VII (BEIR VII) risk model was assumed.