Co-infection of blood borne viruses in blood donors: A cross-sectional study from North India

Abstract Background There are several studies on prevalence of individual infectious disease markers (mono-infection) in donors but none on prevalence of coinfection. Co-infection is significant as it leads to accelerated disease progression. We, therefore, evaluated the prevalence of co-infection a...

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Published inTransfusion and apheresis science Vol. 56; no. 3; pp. 367 - 370
Main Authors Dara, Ravi C, Tiwari, Aseem K, Arora, Dinesh, Aggarwal, Geet, Rawat, Ganesh Singh, Sharma, Jyoti, Acharya, Devi Prasad, Bhardwaj, Gunjan
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2017
Subjects
Adolescent
Adult
Blood Donors
Co-infection
Coinfection
Cross-Sectional Studies
Female
Health technology assessment
Hematology, Oncology and Palliative Medicine
Hepatitis B
Hepatitis B - epidemiology
Hepatitis C
Hepatitis C - epidemiology
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
India
Male
Middle Aged
Retrospective Studies
Young Adult
Co-infection
Human immunodeficiency virus
Hepatitis C
Blood donors
Hepatitis B
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Summary:Abstract Background There are several studies on prevalence of individual infectious disease markers (mono-infection) in donors but none on prevalence of coinfection. Co-infection is significant as it leads to accelerated disease progression. We, therefore, evaluated the prevalence of co-infection among blood donors. Materials and methods The cross-sectional analysis was conducted in blood donors. All donors were tested for anti-HIV I and II, HBsAg, anti-HBC IgM, anti-HCV, Malaria and syphilis by chemiluminescence and ID-NAT assay. All reactive donor samples were confirmed by using confirmatory assays. Donors were grouped as mono-infected and co-infected. The student t -test was used for comparison. Results During the study period, a total of 106,238 blood donors were tested. Mean age of donors was 34.2 years and 94.2% of blood donors were males. 1776 (1.67%) donor samples were confirmed serologically reactive. 1714 (1.61%) samples were reactive for single marker (mono-infected) while 62 (0.05%) donors’ samples exhibited co-infection. 18 donors were positive for HBV+HCV followed by HIV +syphilis (14). Conclusion We report for the first time the prevalence of different co-infection patterns in blood donors. Co-infection influence the disease progression; it would be important to investigate the co-infection prevalence in larger sample size.
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ISSN:1473-0502
1878-1683
DOI:10.1016/j.transci.2017.02.004