The role of dissolved carbon dioxide in both the decline in rumen pH and nutritional diseases in ruminants

• Published in: Animal feed science and technology Vol. 219; pp. 268 - 279
• Main Author: Laporte-Uribe, José A.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2016
• Subjects: Acidosis; Dissolved CO2; Gas holdup; Nutritional diseases; Rumen pH; Volatile fatty acids; Dissolved CO2; Gas holdup; AD; pCO2; H3O; CO2; H; dCO2; Nutritional diseases; H2CO3; Volatile fatty acids; OH; SARA; Acidosis; HCO3; Rumen pH
• ISSN: 0377-8401; 1873-2216
• DOI: 10.1016/j.anifeedsci.2016.06.026

•Rumen pH is the balance between bases (HCO3−) and acids (dCO2) in the solution. Thus, Low rumen pH (acidosis) reflects high dCO2 concentrations.•The decline in rumen CO2 fugacity (CO2 holdup), promoted by modern diets, leads to an even larger CO2 gradient between the blood and the fluid.•Dissolved CO2 is a biologically active molecule that diffuses freely through the rumen epithelia into the blood.•High blood CO2, or hypercapnia, leads to respiratory and metabolic acidosis, syndromes closer associated to rumen acidosis.•Other syndromes associated to acidosis might be also a consequence of high rumen dCO2 concentrations, CO2 holdup and hypercapnia. Rumen pH has been central to theories of nutritional disease and nutrient digestion in ruminants for decades. In particular, rumen pH is the measurement of a physical phenomenon that describes the balance between bases and acids in a solution. Here, I take a closer look at rumen pH and suggest that its decline during acidosis is a sign of an increased concentration of dissolved carbon dioxide (dCO2), which is the acid in the main buffer system. Rumen dCO2 concentrations are thought to be constant and low, but modern feeding practices can lead to carbon dioxide (CO2) holdup, which is defined as a decline in CO2 fugacity due to changes in the physicochemical properties of the rumen liquor. Gas holdup might thus be responsible for increasing rumen dCO2 concentrations, with a concomitant pH decline. Dissolved CO2 is a biologically active molecule that directly influences bacterial metabolism and that, if found at high concentrations, might enhance rumen CO2 diffusion into the blood, leading to hypercapnia or high blood CO2 concentrations. Hypercapnia has known cellular and physiological effects that are closely associated with rumen acidosis. In this review, I discuss the implication of a high rumen dCO2 concentration for the onset of nutritional diseases and highlight the need to explore rumen acidosis from a physicochemical point of view and beyond pH decline.