Structural features and anticancer mechanisms of pectic polysaccharides: A review

• Published in: International journal of biological macromolecules Vol. 209; no. Pt A; pp. 825 - 839
• Main Authors: Yue, Fangfang, Xu, Jiaxin, Zhang, Sitan, Hu, Xinyu, Wang, Xin, Lü, Xin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2022
• Subjects: Anticancer mechanism; Apoptosis; Gastrointestinal Microbiome; Immune and intestinal microbe; Pectic polysaccharides structural; Pectins - pharmacology; Pectins - therapeutic use; Polysaccharides - metabolism; Polysaccharides - pharmacology; Polysaccharides - therapeutic use; Pectic polysaccharides structural; Immune and intestinal microbe; Anticancer mechanism
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2022.04.073

The anticancer activity of pectic polysaccharides (PPs) was proved by numerous studies, and which also indicated that the bioactivity of PPs was closely related to its complicated structures. Based on the summary and analysis about structure characteristics and corresponding enzymatic process of the reported PPs, the anticancer mechanism and related structural features were systematically clarified. It was found that not only the direct effects on the cancer cells by proliferation inhibition or apoptosis, but also the regulation of immune system, gut microbiota and gut metabolism as indirect effects, jointly played important roles in the anticancer of PPs. Nevertheless, during the study of PPs as promising anticancer components, the exact structure-function relationship, digestion process in vivo, and comprehensive action mechanism are still not well understanding. With the unveiling of the proposed issues, it is believed that PPs are promising to be exploited as effective cancer therapy/adjunctive therapy drugs or functional foods.