Protective effect of α-lipoic acid against α-cypermethrin-induced changes in rat cerebellum

• Published in: Journal of chemical neuroanatomy Vol. 86; pp. 52 - 58
• Main Authors: Elsawy, H., Al-Omair, M.A., Sedky, A., Al-Otaibi, L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2017
• Subjects: Acetylcholinesterase - metabolism; Animals; Antioxidants - metabolism; Cerebellum; Cerebellum - drug effects; Cerebellum - metabolism; Cerebellum - pathology; gamma-Aminobutyric Acid - metabolism; Insecticides - antagonists & inhibitors; Insecticides - toxicity; Lipid Peroxidation; Male; Malondialdehyde - metabolism; Neuroprotective Agents - pharmacology; Oxidative Stress - drug effects; Pyrethrins - antagonists & inhibitors; Pyrethrins - toxicity; Rats; Rats, Wistar; Thioctic Acid - pharmacology; Toxicity; α-Cypermethrin; α-Lipoic acid; α-Lipoic acid; Cerebellum; Toxicity; α-Cypermethrin
• ISSN: 0891-0618; 1873-6300
• DOI: 10.1016/j.jchemneu.2017.08.005

Alfa cypermethrin is a pyrethroids extensively used as ectoparasiticide in domestic animals, insecticidal spray on cotton, vegetables and other crops and to kill cockroaches, fleas and termites in house and other buildings. Previous studies have shown the adverse effect of α -cypermethrin on brain. This study was planned to evaluate the possible role of α-lipoic acid in α -cypermethrin induced toxicity in brain of male albino rats. Rats were divided into four groups. The control, α-cypermethrin, α-lipoic acid and α -cypermethrin plus α-lipoic acid treated groups. The duration of the experiment was four weeks. Our results showed that the administration of α-cypermethrin caused a significant decreased in γ- aminobutyric acid level, acetylcholinesterase, catalase, superoxide dismutase activities and increase in lipid peroxidation in cerebellum. Furthermore, the co-administration of α-lipoic acid mitigates the toxicity of α-cypermethrin by partially normalizing the biochemical parameters. The biochemical observations were supported by histopathological examinations. The findings of this investigation suggest that α-lipoic acid may play a protective role against α-cypermethrin induced toxicity in cerebellum of treated rats.