Taurine Prevents Glucose-Induced Lipid Peroxidation and Increased Collagen Production in Cultured Rat Mesangial Cells

Hyperglycemia is directly involved in the development of diabetic nephropathy. A high glucose concentration promotes membrane lipid peroxidation and stimulates collagen production in a variety of cultured cells. Taurine, a sulfur amino acid, is an endogenous antioxidant and antifibrotic agent. We te...

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Published inBiochemical and biophysical research communications Vol. 191; no. 2; pp. 759 - 765
Main Authors Trachtman, H., Futterweit, S., Bienkowski, R.S.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 15.03.1993
Elsevier
Subjects
Animals
Biological and medical sciences
Cells, Cultured
Collagen - biosynthesis
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glomerular Mesangium - cytology
Glomerular Mesangium - metabolism
Glucose - physiology
Lipid Peroxidation
Medical sciences
Rats
Taurine - physiology
Endocrinopathy
Taurine
Rat
Mesangial cell
Diabetes mellitus
Rodentia
Lipids
Biosynthesis
Antioxidant
In vitro
Renal glomerulus
Vertebrata
Hyperglycemia
Mammalia
Animal
Collagen
Complication
Mechanism of action
Peroxidation
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Summary:Hyperglycemia is directly involved in the development of diabetic nephropathy. A high glucose concentration promotes membrane lipid peroxidation and stimulates collagen production in a variety of cultured cells. Taurine, a sulfur amino acid, is an endogenous antioxidant and antifibrotic agent. We tested whether taurine ameliorates the above effects of elevated ambient glucose on renal cells in vitro. Raising glucose concentration from 5.6 to 33.3 mM enhanced lipid peroxidation in rat mesangial cells, as assessed by malondialdehyde and conjugated diene content, and increased collagen production by 59%. Taurine prevented both glucose-induced effects in mesangial cells. In contrast, neither high glucose nor taurine, alone or in combination, affected lipid peroxidation or collagen production in MDCK or LLC-PK 1 cells, derived from renal tubular epithelium. These results indicate that taurine may be a useful therapeutic agent to attenuate diabetic glomerulosclerosis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1993.1282