Exploring the antibacterial potential of magnetite/Quince seed mucilage/Ag nanocomposite: Synthesis, characterization, and activity assessment

• Published in: International journal of biological macromolecules Vol. 249; p. 126120
• Main Authors: Gharaati, Ahmad Reza, Allafchian, Alireza, Karimzadeh, Fathallah
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.09.2023
• Subjects: Ag NPs; Antibacterial activity; Magnetic nanocomposite; Magnetite nanoparticles; QSM; MIC; FT-IR; DLS; QSM; XRD; Magnetic nanocomposite; MBC; NPs; VSM; Magnetite nanoparticles; Ag NPs; DBP; EDX; PI; Antibacterial activity; SEM; TEM; ICP-OES
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2023.126120

In this study, we present a novel core-shell antibacterial agent designed for water disinfection purposes. The nanocomposite is synthesized by combining quince seed mucilage (QSM) as the shell material and Fe3O4 as the core material. The integration of antibacterial silver nanoparticles (Ag NPs) onto the QSM shell effectively prevents agglomeration of the Ag NPs, resulting in a larger contact surface area with bacteria and consequently exhibiting enhanced antibacterial activity. The incorporation of magnetic Fe3O4 NPs with a saturation magnetization of 55.2 emu·g−1 as the core allows for easy retrieval of the nanocomposites from the medium using a strong magnetic field, enabling their reusability. The Fe3O4/QSM/Ag nanocomposite is extensively characterized using XRD, FT-IR, VSM, DLS, FE-SEM, and TEM techniques. The characterization results confirm the successful synthesis of the nanocomposites, with an average particle size of 73 nm and no contamination or impurities detected. The nanocomposites exhibit superparamagnetic properties, with a saturated magnetization of 22.69 emu·g−1, ensuring facile separation from water. The antibacterial activity of the synthesized nanocomposite is evaluated using the disk diffusion method against both Gram-positive and Gram-negative bacteria. The results reveal excellent antibacterial efficacy, with minimum inhibition concentrations (MIC) of 0.8 mg·mL−1 against E. coli and S. typhimurium. Furthermore, the measurement of released silver ions in water using ICP-OES indicates a low concentration of remaining silver ions in the medium, highlighting the controlled release of antimicrobial agents. Overall, this study provides valuable insights into the development of advanced antibacterial agents for water disinfection applications, offering potential solutions to combat microbial contamination effectively. •A novel Fe3O4/QSM/Ag nanocomposite with enhanced antibacterial activity was synthesized for effective water disinfection•Nanocomposite exhibits excellent antibacterial activity, with MIC values of 0.8 mg.mL-1 against E. coli and S. typhimurium•Characterization confirms successful synthesis, favorable particle size, and successful coating of Fe3O4 NPs with QSM•The nanocomposite demonstrates controlled release of silver ions and low toxicity, addressing concerns about health hazards