Management of Advanced Juvenile Granulosa Cell Tumor of the Ovary

Juvenile granulosa cell tumors (JGCTs) of the ovary are rare. They usually present in children and adolescents. About 90% are diagnosed in early stage (FIGO I) with a favorable prognosis. More advanced stages (FIGO II–IV) have a poor clinical outcome. We report two cases of short-term, disease-free...

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Published inGynecologic oncology Vol. 64; no. 2; pp. 282 - 284
Main Authors Powell, John L., Otis, Christopher N.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 01.02.1997
Elsevier
Subjects
Adolescent
Biological and medical sciences
Combined Modality Therapy
Female
Female genital diseases
Granulosa Cell Tumor - pathology
Granulosa Cell Tumor - therapy
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Neoplasm Staging
Ovarian Neoplasms - pathology
Ovarian Neoplasms - therapy
Remission Induction
Tumors
Antineoplastic agent
Human
Drug combination
Etoposide
Malignant tumor
Female genital diseases
Case study
Podophyllotoxine derivatives
Ovarian diseases
Ovary
Chemotherapy
Conservative surgery
Cell line
Treatment
Carboplatin
Female
Advanced stage
Granulosa
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Summary:Juvenile granulosa cell tumors (JGCTs) of the ovary are rare. They usually present in children and adolescents. About 90% are diagnosed in early stage (FIGO I) with a favorable prognosis. More advanced stages (FIGO II–IV) have a poor clinical outcome. We report two cases of short-term, disease-free survival of teenagers with Stage III JGCTs treated with aggressive debulking and thorough staging but conservative surgery relative to the uterus and contralateral tube and ovary plus carboplatin and etoposide chemotherapy. These results are encouraging, but the best treatment for extensive and recurrent disease has yet to be determined.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:0090-8258
1095-6859
DOI:10.1006/gyno.1996.4563