Leveraging advances in chemistry to design biodegradable polymeric implants using chitosan and other biomaterials

• Published in: International journal of biological macromolecules Vol. 169; pp. 414 - 427
• Main Authors: Sharma, Bhasha, Sharma, Shreya, Jain, Purnima
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2021
• Subjects: Absorbable Implants - trends; Animals; Biocompatible Materials - chemistry; Biopolymer; Chitosan; Chitosan - chemistry; Collagen; Collagen - metabolism; Gelatin; Gelatin - chemistry; Humans; Implants; Nanotechnology; Nanotechnology - methods; Polymers - chemistry; Printing, Three-Dimensional - trends; Therapeutic applications; Tissue Engineering - methods; Tissue Scaffolds - chemistry; Therapeutic applications; Gelatin; Collagen; Biopolymer; Implants; Chitosan; Nanotechnology
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2020.12.112

The metamorphosis of biodegradable polymers in biomedical applications is an auspicious myriad of indagation. The utmost challenge in clinical conditions includes trauma, organs failure, soft and hard tissues, infection, cancer and inflammation, congenital disorders which are still not medicated efficiently. To overcome this bone of contention, proliferation in the concatenation of biodegradable materials for clinical applications has emerged as a silver bullet owing to eco-friendly, nontoxicity, exorbitant mechanical properties, cost efficiency, and degradability. Several bioimplants are designed and fabricated in a way to reabsorb or degrade inside the body after performing the specific function rather than eliminating the bioimplants. The objective of this comprehensive is to unfurl the anecdote of emerging biological polymers derived implants including silk, lignin, soy, collagen, gelatin, chitosan, alginate, starch, etc. by explicating the selection, fabrication, properties, and applications. Into the bargain, emphasis on the significant characteristics of current discernment and purview of nanotechnology integrated biopolymeric implants has also been expounded. This robust contrivance shed light on recent inclinations and evolution in tissue regeneration and targeting organs followed by precedency and fly in the ointment concerning biodegradable implants evolved by employing fringe benefits provided by 3D printing technology for building tissues or organs construct for implantation.