Abnormalities in T Cell Interactions with the Extracellular Matrix Proteins in a Patient with Wegener's Granulomatosis

• Published in: Clinical immunology and immunopathology Vol. 69; no. 2; pp. 149 - 154
• Main Authors: Górski, Andrzej, Piekarczyk, Janusz, Skurzak, Henryk, Nowaczyk, Maria, Dybowska, Beata, St e ̧ pień-Sopniewska, Barbara, Korczak-Kowalska, Graźyna, Pazdur, Jacek, Filipowicz-Sosnowska, Anna
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.11.1993; New York, NY Academic Press; Boston
• Subjects: Biological and medical sciences; Cell Adhesion - physiology; Cells, Cultured; Collagen - physiology; Endothelium, Vascular - pathology; Extracellular Matrix Proteins - physiology; Female; Fibronectins - physiology; Granulomatosis with Polyangiitis - immunology; Granulomatosis with Polyangiitis - pathology; Humans; Immunophenotyping; Lymphocyte Activation - physiology; Male; Medical sciences; Middle Aged; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; T-Lymphocytes - immunology; T-Lymphocytes - physiology; Vasculitis - immunology; Vasculitis - pathology; Human; Endothelial cell; Pathogenesis; Cardiovascular disease; Wegener granulomatosis; Cell cell interaction; Molecular interaction; Vascular disease; Proteins; Vasculitis; Systemic disease; T-Lymphocyte; Extracellular matrix
• ISSN: 0090-1229; 1090-2341
• DOI: 10.1006/clin.1993.1163

T cell interactions with the extracellular matrix proteins and cultured human endothelium were studied in a patient with Wegener's granulomatosis and other cases of vasculitis. Markedly enhanced costimulation of T-lymphoproliferative responses mediated by collagen and fibronectin were found in patients with severe forms of vasculitis, particularly with necrotizing changes. In addition, enhanced adhesion to collagen IV was found in the Wegener patient. T cell adhesion to resting and inflamed endothelium varied from normal to increased.