Validation of an EEG seizure detection paradigm optimized for clinical use in a chronically implanted subcutaneous device

• Published in: Journal of neuroscience methods Vol. 358; p. 109220
• Main Authors: Bacher, Dan, Amini, Andrew, Friedman, Daniel, Doyle, Werner, Pacia, Steven, Kuzniecky, Ruben
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2021
• Subjects: Algorithm; Band-pass filters; EEG; Electroencephalography; Epilepsy; Intracranial; Linear detector; Low power; Scalp; Subgaleal; Ultra-long-term EEG monitoring; Band-pass filters; Ultra-long-term EEG monitoring; Intracranial; Linear detector; Scalp; EEG; Epilepsy; Subgaleal; Electroencephalography; Low power; Algorithm
• ISSN: 0165-0270; 1872-678X; 1872-678X
• DOI: 10.1016/j.jneumeth.2021.109220

•We report intracranial EEG validation of a subcutaneous EEG ictal detection paradigm.•The algorithm obtained a sensitivity 97 %, specificity 93 % and accuracy of 93 %.•A simple seizure detection algorithm using subcutaneous EEG signals is possible. Many electroencephalography (EEG) based seizure detection paradigms have been developed and validated over the last two decades. The majority of clinical approaches use scalp or intracranial EEG electrodes. Scalp EEG is limited by patient discomfort and short duration of useful EEG signals. Intracranial EEG involves an invasive surgical procedure associated with significant risk making it unsuitable for widespread use as a practical clinical biometric. A less invasive EEG monitoring approach, that is between invasive intracranial procedures and noninvasive methods, would fill the need of a safe, accurate, chronic (ultra-long term) and objective seizure detection method. We present validation of a continuous EEG seizure detection paradigm using human single-channel EEG recordings from subcutaneously placed electrodes that could be used to fulfill this need. Ten-minute long sleep, awake and ictal EEG epochs obtained from 21 human subjects with subscalp electrodes and validated against simultaneous iEEG recordings were analyzed by three experienced clinical neurophysiologists. The 201subscalp EEG time series epochs where classified as diagnostic for awake, asleep, or seizure by the clinicians who were blinded to all other information. Seventy of the epochs were classified in this way as representing seizure activity. A subject specific seizure detection algorithm was trained and then evaluated offline for each patient in the data set using the expert consensus classification as the gold standard. The average seizure detection performance of the algorithm across 21 subjects exceeded 90 % accuracy: 97 % sensitivity, 91 % specificity, and 93 % accuracy. For 19 of 21 patient datasets the algorithm achieved 100 % sensitivity. For 15 of 21 patients, the algorithm achieved 100 % specificity. For 13 of 21 patients the algorithm achieved 100 % accuracy. No comparable published methods are available for subgaleal EEG seizure detection. These findings suggest that a simple seizure detection algorithm using subcutaneous EEG signals could provide sufficient accuracy and clinical utility for use in a low power, long-term subcutaneous brain monitoring device. Such a device would fill a need for a large number of people with epilepsy who currently have no means for accurately quantifying their seizures thereby providing important information to healthcare providers not currently available.