Innate Immunity in Resistance to HIV Infection

• Published in: The Journal of infectious diseases Vol. 202; no. Supplement-3; pp. S361 - S365
• Main Authors: Biasin, Mara, Clerici, Mario, Piacentini, Luca
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford The University of Chicago Press 01.11.2010; University of Chicago Press; Oxford University Press
• Subjects: Agonists; AIDS; APOBEC-3G Deaminase; Biological and medical sciences; Cytidine Deaminase - immunology; Cytokines; Fundamental and applied biological sciences. Psychology; HIV; HIV - immunology; HIV infections; HIV Infections - immunology; Human viral diseases; Humans; Immunity, Innate; Infections; Infectious diseases; Interleukin-22; Interleukins - immunology; Killer Cells, Natural - immunology; Medical sciences; Microbiology; Natural killer cells; Receptors; Serum Amyloid A Protein - immunology; Toll like receptors; Toll-Like Receptors - immunology; Vaccination; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Infection; Resistance; Immunopathology; Viral disease; Natural immunity; AIDS; Immune deficiency
• ISSN: 0022-1899; 1537-6613; 1537-6613
• DOI: 10.1086/655965

Resistance to human immunodeficiency virus (HIV) infection in subjects who do not seroconvert despite multiple exposures to the virus and to the progression to AIDS in HIV-infected individuals depends on multiple factors involving both the innate and the adaptive immune system. The contribution of natural immunity in preventing HIV infection has so far received little attention, but many recently published articles suggest a key role for Toll-like receptors, natural killer cells, interleukin-22, acute-phase amyloid A protein, and APOBEC3G in conferring resistance to HIV infection. The study of these factors will shed light on HIV pathogenesis and contribute to the development of new therapeutic approaches to this elusive disease.