Selenium release kinetics and mechanism from Cordyceps sinensis exopolysaccharide-selenium composite nanoparticles in simulated gastrointestinal conditions

• Published in: Food chemistry Vol. 350; p. 129223
• Main Authors: Xiao, Yidong, Huang, Qilin, Zheng, Zhaomin, Ma, Huiyu
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.07.2021
• Subjects: Biomimetics; Cordyceps - chemistry; Exopolysaccharide-selenium nanoparticles (EPS-SeNPs); Fungal Polysaccharides - chemistry; Gastrointestinal condition; Gastrointestinal Tract - metabolism; Kinetics; Kinetics model; Nanoparticles - chemistry; Release mechanism; Se/EPS ratio; Selenium - chemistry; Exopolysaccharide-selenium nanoparticles (EPS-SeNPs); Kinetics model; Se/EPS ratio; Gastrointestinal condition; Release mechanism
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2021.129223

•EPS-SeNPs had a bigger size and ambiguous boundary post gastrointestinal digestion.•Se release from EPS-SeNPs (Se/EPS = 1/1 and 4/3 in SGF) followed a Fickian diffusion.•Se release from EPS-SeNPs (Se/EPS = 1/20 in SIF) was governed by erosion (chain relaxation).•Se release (Se/EPS = 1/1 and 4/3 in SIF) was governed by both diffusion and erosion.•The Se/EPS = 1/20 sample was stable in SGF and active in SIF with controlled Se release potential. This work investigated selenium (Se) release kinetics and mechanism from exopolysaccharide-selenium nanoparticles (EPS-SeNPs, Se/EPS = 1/20, 1/1 and 4/3) in simulated gastric (SGF) and intestinal fluids (SIF) using kinetics models of Zero order, First order, Higuchi, Hixson-Crowell and Korsmeyer-Peppas. EPS-SeNPs showed an increase in size from 80–125 nm to 250–320 nm and more ambiguous boundary after gastrointestinal digestion. Se/EPS ratio and pH had significant influence on Se release. Se release kinetics from EPS-SeNPs (Se/EPS = 1/1 and 4/3 in SGF) followed a classical Fickian diffusion, in contrast to an erosion governed by macromolecular chains relaxation for Se/EPS = 1/20 in SIF. Se release from EPS-SeNPs (Se/EPS = 1/1 and 4/3 in SIF) was well-fitted to Korsmeyer-Peppas model and followed a non-Fickian mechanism controlled by both diffusion and erosion. Additionally, EPS-SeNPs (Se/EPS = 1/20) showed a low Se release after SGF digestion, but a high release after SIF digestion, suggesting its application in controlled release of Se-enriched supplements for Se-deficiency treatment.