Selenium release kinetics and mechanism from Cordyceps sinensis exopolysaccharide-selenium composite nanoparticles in simulated gastrointestinal conditions
•EPS-SeNPs had a bigger size and ambiguous boundary post gastrointestinal digestion.•Se release from EPS-SeNPs (Se/EPS = 1/1 and 4/3 in SGF) followed a Fickian diffusion.•Se release from EPS-SeNPs (Se/EPS = 1/20 in SIF) was governed by erosion (chain relaxation).•Se release (Se/EPS = 1/1 and 4/3 in...
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Published in | Food chemistry Vol. 350; p. 129223 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
15.07.2021
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Subjects | |
Online Access | Get full text |
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Summary: | •EPS-SeNPs had a bigger size and ambiguous boundary post gastrointestinal digestion.•Se release from EPS-SeNPs (Se/EPS = 1/1 and 4/3 in SGF) followed a Fickian diffusion.•Se release from EPS-SeNPs (Se/EPS = 1/20 in SIF) was governed by erosion (chain relaxation).•Se release (Se/EPS = 1/1 and 4/3 in SIF) was governed by both diffusion and erosion.•The Se/EPS = 1/20 sample was stable in SGF and active in SIF with controlled Se release potential.
This work investigated selenium (Se) release kinetics and mechanism from exopolysaccharide-selenium nanoparticles (EPS-SeNPs, Se/EPS = 1/20, 1/1 and 4/3) in simulated gastric (SGF) and intestinal fluids (SIF) using kinetics models of Zero order, First order, Higuchi, Hixson-Crowell and Korsmeyer-Peppas. EPS-SeNPs showed an increase in size from 80–125 nm to 250–320 nm and more ambiguous boundary after gastrointestinal digestion. Se/EPS ratio and pH had significant influence on Se release. Se release kinetics from EPS-SeNPs (Se/EPS = 1/1 and 4/3 in SGF) followed a classical Fickian diffusion, in contrast to an erosion governed by macromolecular chains relaxation for Se/EPS = 1/20 in SIF. Se release from EPS-SeNPs (Se/EPS = 1/1 and 4/3 in SIF) was well-fitted to Korsmeyer-Peppas model and followed a non-Fickian mechanism controlled by both diffusion and erosion. Additionally, EPS-SeNPs (Se/EPS = 1/20) showed a low Se release after SGF digestion, but a high release after SIF digestion, suggesting its application in controlled release of Se-enriched supplements for Se-deficiency treatment. |
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ISSN: | 0308-8146 1873-7072 |
DOI: | 10.1016/j.foodchem.2021.129223 |