Visible and UV-curable chitosan derivatives for immobilization of biomolecules

• Published in: International journal of biological macromolecules Vol. 104; no. Pt B; pp. 1611 - 1619
• Main Authors: Kim, Eun-Hye, Han, Ga-Dug, Kim, Jae-Won, Noh, Seung-Hyun, Lee, Jae-Gwan, Ito, Yoshihiro, Son, Tae-Il
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017
• Subjects: Biomolecule; Chitosan; Chitosan - chemistry; Humans; Immobilized Proteins - chemistry; Photo-immobilization; Ultraviolet Rays; Biomolecule; Photo-immobilization; Chitosan
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2017.04.115

Chitosan, which has many biocompatible properties, is used widely in medical field like wound healing, drug delivery and so on. Chitosan could be used as a biomaterial to immobilize protein-drug. There are many methods to immobilize protein-drug, but they have some drawbacks such as low efficiency and denaturation of protein. Therefore, photo-immobilization method is suggested to immobilize protein-drug. Photo-immobilization method is simple-reaction and also needs no additional crosslinking reagent. There has been some effort to modify chitosan to have an ability of photo-immobilization. Generally, visible and UV light reactive chitosan derivatives were prepared. Various types of photo-curable chitosan derivatives showed possibility for application to medical field. For example, they showed ability for protein-immobilization and some of them showed wound-healing effect, anti-adhesive effect, or property to interact directly with titanium surface. In this study, we introduce many types of photo-curable chitosan derivative and their possibility of medical application.