In Vivo and In Vitro Degradation Behavior of Magnesium Alloys as Biomaterials

• Published in: Journal of materials science & technology Vol. 28; no. 3; pp. 261 - 267
• Main Authors: Xue, Dingchuan, Yun, Yeoheung, Tan, Zongqing, Dong, Zhongyun, Schulz, Mark J.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.03.2012
• Subjects: Bio-degradation rate; Biocompatibility; Biomedical materials; In vitro testing; In vitro/in vivo; In vivo testing; In vivo tests; Magnesium base alloys; Mg/Mg alloys; Simulation; Surgical implants; testing; 体内环境; 体外降解; 扫描电子显微镜; 植入材料; 生物材料; 生物相容性; 腐蚀行为; 镁合金; Biocompatibility; In vitro/in vivo; Mg/Mg alloys; Bio-degradation rate; testing
• ISSN: 1005-0302; 1941-1162
• DOI: 10.1016/S1005-0302(12)60051-6

The corrosion behavior of pure Mg,AZ31,and AZ91D were evaluated in various in vitro and in vivo environments to investigate the potential application of these metals as biodegradable implant materials.DC polarization tests and immersion tests were performed in different simulated body solutions,such as distilled（DI） water,simulated body fluid（SBF） and phosphate buffered solution（PBS）.Mg/Mg alloys were also implanted in different places in a mouse for in vivo weight loss and biocompatibility investigations.The in vivo subcutis bio-corrosion rate was lower than the corrosion rate for all of the in vitro simulated corrosive environments.The Mg/Mg alloys were biocompatible based on histology results for the liver,heart,kidney,skin and lung of the mouse during the two months implantation.Optical microscopy and scanning electron microscopy were carried out to investigate the morphology and topography of Mg/Mg alloys after immersion testing and implantation to understand the corrosion mechanisms.