CASP3 protein expression by flow cytometry in Down’s syndrome subjects

• Published in: Human cell : official journal of Human Cell Research Society Vol. 27; no. 1; pp. 43 - 45
• Main Authors: Salemi, Michele, Condorelli, Rosita A., Romano, Corrado, Concetta, Barone, Romano, Carmelo, Salluzzo, Maria Grazia, Bosco, Paolo, Calogero, Aldo E.
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.01.2014
• Subjects: Adult; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Apoptosis - genetics; Biomedical and Life Sciences; Caspase 3 - genetics; Caspase 3 - metabolism; Cell Biology; Cells, Cultured; Down Syndrome - genetics; Down Syndrome - pathology; Female; Fibroblasts - metabolism; Fibroblasts - pathology; Flow Cytometry; Gene Expression - genetics; Gynecology; Humans; Letter to the Editor; Life Sciences; Male; Middle Aged; Oncology; Reproductive Medicine; Stem Cells; Surgery; Up-Regulation; Fibroblasts; Flow cytometry; CASP3 gene; Down syndrome

Down’s syndrome (DS), the most common chromosomal disorder, is caused by 21 trisomy and is featured by intellectual disability. Subjects with DS can develop some traits of Alzheimer disease (AD) at an earlier age than subjects without trisomy 21. Apoptosis is a programmed cell death process under bo...