Analgesic effects of JCM-16021 on neonatal maternal separation-induced visceral pain in rats

• Published in: World journal of gastroenterology : WJG Vol. 16; no. 7; pp. 837 - 845
• Main Authors: Bian, Zhao-Xiang, Zhang, Man, Han, Quan-Bin, Xu, Hong-Xi, Sung, Joseph J Y
• Format: Journal Article
• Language: English
• Published: United States School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,China%Institute of Chinese Medicine,The Chinese University of Hong Kong,Hong Kong,China%Chinese Medicine Laboratory,Hong Kong Jockey Club Institute of Chinese Medicine,Hong Kong,China%Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong,China 21.02.2010; The WJG Press and Baishideng
• Subjects: Administration, Oral; Analgesics - administration & dosage; Analgesics - pharmacology; Animals; Animals, Newborn; Anxiety, Separation - complications; Anxiety, Separation - psychology; Colon - innervation; Colon - metabolism; Colon - physiopathology; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - pharmacology; Electromyography; Enterochromaffin Cells - drug effects; Enterochromaffin Cells - metabolism; Female; Hydroxyindoleacetic Acid - metabolism; Hypersensitivity - drug therapy; Hypersensitivity - metabolism; Hypersensitivity - physiopathology; Hypersensitivity - psychology; Male; Maternal Deprivation; Original; Pain - drug therapy; Pain - metabolism; Pain - physiopathology; Pain - psychology; Pain Measurement; Pain Threshold - drug effects; Pressure; Rats; Rats, Sprague-Dawley; Serotonin - metabolism; Serotonin Plasma Membrane Transport Proteins - metabolism; Signal Transduction - drug effects; Time Factors; Herbal medicine; Analgesia effect; Serotonin pathway; Neonatal maternal separation; Visceral hyperalgesia
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v16.i7.837

AIM:To investigate the pharmacological effect of JCM-16021,a Chinese herbal formula,and its underlying mechanisms.METHODS:JCM-16021 is composed of seven herbal plant materials.All raw materials of the formula were examined according to the quality control criteria listed in the Chinese Pharmacopeia(2005).In a neonatal maternal separation(NMS)model,male SpragueDawley rats were submitted to daily maternal separation from postnatal day 2 to day 14,or no specific handling(NH).Starting from postnatal day 60,rats...