A case of pancreatic neuroendocrine tumor with multiple cystic components of various sizes

• Published in: Clinical journal of gastroenterology Vol. 11; no. 1; pp. 87 - 91
• Main Authors: Yasumoto, Makiko, Okabe, Yoshinobu, Sugiyama, Gen, Naito, Yoshiki, Nakayama, Masamichi, Hisaka, Toru, Ishikawa, Hiroto, Horiuchi, Hiroyuki, Kunou, Yukiko, Ushijima, Tomoyuki, Ishida, Yusuke, Tsuruta, Osamu, Torimura, Takuji
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.02.2018
• Subjects: Abdominal Surgery; Case Report; Colorectal Surgery; Gastroenterology; Hepatology; Medicine; Medicine & Public Health; Surgical Oncology; Microcysts; EUS-FNA; Pancreatic neuroendocrine tumor
• ISSN: 1865-7257; 1865-7265
• DOI: 10.1007/s12328-017-0798-0

The patient was a 51-year-old woman who, while undergoing a thorough health checkup, was found to have a tumor (measuring 60 mm in diameter) in the tail of the pancreas by abdominal ultrasonography. Contrast-enhanced computed tomography revealed delayed contrast enhancement; the tumor also contained numerous low-absorption areas showing poor contrast enhancement. On magnetic resonance imaging, the tumor was visualized as having high signal intensity areas inside the tumor on T2-weighted images. Positron emission tomography revealed an abnormal accumulation in the area corresponding to the tumor. Endoscopic ultrasonography (EUS) revealed a relatively hyperechoic solid area, with a number of echo-free areas of various sizes that assumed a honeycomb appearance. EUS-guided fine needle aspiration was carried out targeting the solid area within the tumor, which led to a diagnosis of pancreatic neuroendocrine tumor (PNET). Histopathological examination of the resected specimen revealed that the tumor was composed of numerous cysts of various sizes and solid components. The cysts contained no evidence of necrosis or bleeding. Immunohistochemically, the cystic as well as solid components were CD56 (+), synaptophysin (+) and chromogranin A (+) with MIB1 labeling index of 5%. On the basis of these findings, the final diagnosis was PNET (G2).