Rapid adjustment of theophylline: a kinetic model

This study was designed to test the validity and applicability of basic kinetic equations to describe theophylline disposition. The method involves early determination of clearance from a nonsteady-state level, dosage adjustment on the basis of the estimated clearance, and measurement of serum theop...

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Bibliographic Details
Published inDrug intelligence & clinical pharmacy Vol. 18; no. 6; p. 519
Main Authors Postelnick, M J, Lesher, C A, Steiner, V I, Nitti, J R, Springborn, P W, Jaresko, G S
Format Journal Article
LanguageEnglish
Published United States 01.06.1984
Subjects
Adolescent
Adult
Aged
Aminophylline - administration & dosage
Child
Child, Preschool
Female
Humans
Infusions, Parenteral
Kinetics
Male
Middle Aged
Models, Biological
Prospective Studies
Theophylline - administration & dosage
Theophylline - blood
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Summary:This study was designed to test the validity and applicability of basic kinetic equations to describe theophylline disposition. The method involves early determination of clearance from a nonsteady-state level, dosage adjustment on the basis of the estimated clearance, and measurement of serum theophylline concentration at a point very near steady state. To test the method, a 32-patient study group was examined. The results were encouraging, with the actual mean level 19-28 hours after dosage adjustment being 13.4 micrograms/ml (SD, 3.1) as compared with a projected level of 13.2 micrograms/ml (SD, 2.9). Although further investigation is necessary, these findings indicate that within the limitations of the population studied this approach is a reliable and rapid method to achieve therapeutic serum theophylline levels while at the same time avoiding toxicity and subtherapeutic responses.
ISSN:0012-6578
DOI:10.1177/106002808401800611